BDBM249294 US10017501, Compound 1020-90::US9458145, 1020-90

SMILES COc1nc2c(cc(cc2[nH]1)-c1c(C)noc1C)-c1c(C)ccc2ncccc12

InChI Key InChIKey=ZHSYNUAULROSRV-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 249294   

TargetBromodomain-containing protein 4 [75-147](Human)
Gilead Sciences

US Patent
LigandPNGBDBM249294(US9458145, 1020-90 | US10017501, Compound 1020-90)
Affinity DataIC50: 29.9nMpH: 7.5 T: 2°CAssay Description:Binding of the bromodomain BRD4-I to an acetylated histone H4 peptide was measured using a bead-based Amplified Luminescent Proximity Homogeneous Ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/11/2017
Entry Details
US Patent

TargetBromodomain-containing protein 4 [75-147](Human)
Gilead Sciences

US Patent
LigandPNGBDBM249294(US9458145, 1020-90 | US10017501, Compound 1020-90)
Affinity DataIC50: 110nMpH: 7.5 T: 2°CAssay Description:Binding of the two tandem bromodomains, BRD4-1 and BRD4-2, to an acetylated histone H4 peptide was measured using a homogeneous time resolved fluores...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/11/2017
Entry Details
US Patent

TargetBromodomain-containing protein 4 [75-147](Human)
Gilead Sciences

US Patent
LigandPNGBDBM249294(US9458145, 1020-90 | US10017501, Compound 1020-90)
Affinity DataIC50: 110nMAssay Description:Binding of the two tandem bromodomains, BRD4-1 and BRD4-2, to an acetylated histone H4 peptide was measured using a homogeneous time resolved fluores...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2020
Entry Details
US Patent

TargetBromodomain-containing protein 4 [368-440](Human)
Gilead Sciences

US Patent
LigandPNGBDBM249294(US9458145, 1020-90 | US10017501, Compound 1020-90)
Affinity DataIC50: 121nMAssay Description:Binding of the two tandem bromodomains, BRD4-1 and BRD4-2, to an acetylated histone H4 peptide was measured using a homogeneous time resolved fluores...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2020
Entry Details
US Patent

TargetBromodomain-containing protein 4 [368-440](Human)
Gilead Sciences

US Patent
LigandPNGBDBM249294(US9458145, 1020-90 | US10017501, Compound 1020-90)
Affinity DataIC50: 121nMpH: 7.5 T: 2°CAssay Description:Binding of the two tandem bromodomains, BRD4-1 and BRD4-2, to an acetylated histone H4 peptide was measured using a homogeneous time resolved fluores...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/11/2017
Entry Details
US Patent