BDBM252856 US9464076, 8

SMILES CC(=O)c1ccc(C(C)=O)c2sc(cc12)C(=O)Nc1cc(c2ccccc2n1)C(C)(C)O

InChI Key InChIKey=NKBXRRXVZJUZIT-UHFFFAOYSA-N

Data  2 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 252856   

TargetIsoform PDE10A2 of cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (PDE10A2)(Human)
Daiichi Sankyo

US Patent

LigandBDBM252856(US9464076, 8)Copy SMILESCopy InChI

Affinity DataIC50: 12nMpH: 7.5 T: 2°CAssay Description:A human acute lymphoblastic lymphoma T cell line MOLT-4 (which can be purchased under ATCC No. CRL-1582 from ATCC) was cultured in an RPMI1640 medium...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
10/2/2017
Entry Details
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TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Human)
Asubio Pharma

Curated by ChEMBL

LigandBDBM252856(US9464076, 8)Copy SMILESCopy InChI

Affinity DataIC50: 13nMAssay Description:Inhibition of human MOLT4 cell-derived PDE10A using [3H]cAMP as substrate measured after 2 hrs in presence of rolipram/milrinone by topcount methodMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
2/20/2021
Entry Details Article
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