BDBM254157 US10112937, Example 36::US10150765, Example 36::US10703749, Example 36::US9464084, 36

SMILES FC(F)(F)c1cccc(C(=O)OCC2N(CCc3c2ncn3-c2ccccc2)C(=O)c2cccc(c2Cl)C(F)(F)F)c1Cl

InChI Key InChIKey=KEBGPPGXKDCYFN-UHFFFAOYSA-N

Data  12 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 254157   

TargetP2X purinoceptor 7(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM254157(US9464084, 36 | US10112937, Example 36 | US1015076...)
Affinity DataIC50: 3.10nMAssay Description:Antagonist activity at recombinant human P2X7 receptor expressed in 1321N1 cells measured after 30 mins by fluorescence based calcium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetP2X purinoceptor 7(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM254157(US9464084, 36 | US10112937, Example 36 | US1015076...)
Affinity DataIC50: 3.08E+3nMAssay Description:Human or rat P2X7-1321 N1 cells were collected and frozen @−80° C. On the day of the experiment, cell membrane preparations were made according...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2021
Entry Details
US Patent

TargetP2X purinoceptor 7(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM254157(US9464084, 36 | US10112937, Example 36 | US1015076...)
Affinity DataIC50: 3.08E+3nMAssay Description:1321N1 cells expressing the recombinant human, rat or mouse P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2019
Entry Details
US Patent

TargetP2X purinoceptor 7(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM254157(US9464084, 36 | US10112937, Example 36 | US1015076...)
Affinity DataIC50: 3.08E+3nMpH: 7.4Assay Description:1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2019
Entry Details
US Patent

TargetP2X purinoceptor 7(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM254157(US9464084, 36 | US10112937, Example 36 | US1015076...)
Affinity DataIC50: 3.08E+3nMpH: 7.4Assay Description:1321 N1 cells expressing the recombinant human, rat or mouse P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2017
Entry Details
US Patent

TargetP2X purinoceptor 7(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM254157(US9464084, 36 | US10112937, Example 36 | US1015076...)
Affinity DataIC50: 3.39E+3nMpH: 7.4Assay Description:1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2019
Entry Details
US Patent

TargetP2X purinoceptor 7(Rat)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM254157(US9464084, 36 | US10112937, Example 36 | US1015076...)
Affinity DataIC50: 1.01E+4nMAssay Description:Human or rat P2X7-1321 N1 cells were collected and frozen @−80° C. On the day of the experiment, cell membrane preparations were made according...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2021
Entry Details
US Patent

TargetP2X purinoceptor 7(Rat)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM254157(US9464084, 36 | US10112937, Example 36 | US1015076...)
Affinity DataIC50: 1.01E+4nMpH: 7.4Assay Description:1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2019
Entry Details
US Patent

TargetP2X purinoceptor 7(Rat)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM254157(US9464084, 36 | US10112937, Example 36 | US1015076...)
Affinity DataIC50: 1.01E+4nMAssay Description:1321N1 cells expressing the recombinant human, rat or mouse P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2019
Entry Details
US Patent

TargetP2X purinoceptor 7(Rat)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM254157(US9464084, 36 | US10112937, Example 36 | US1015076...)
Affinity DataIC50: 1.01E+4nMpH: 7.4Assay Description:1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2019
Entry Details
US Patent

TargetP2X purinoceptor 7(Rat)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM254157(US9464084, 36 | US10112937, Example 36 | US1015076...)
Affinity DataIC50: 1.01E+4nMpH: 7.4Assay Description:1321 N1 cells expressing the recombinant human, rat or mouse P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2017
Entry Details
US Patent

TargetP2X purinoceptor 7(Rat)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM254157(US9464084, 36 | US10112937, Example 36 | US1015076...)
Affinity DataIC50: 1.01E+4nMAssay Description:Antagonist activity at recombinant rat P2X7 receptor expressed in 1321N1 cells measured after 30 mins by fluorescence based calcium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed