BDBM25436 4-[(1R,2R)-2-hydroxycyclohexyl]-2-(trifluoromethyl)benzonitrile::PF-0998425::arylcyclohexanol, (-)-6a

SMILES O[C@@H]1CCCC[C@@H]1c1ccc(C#N)c(c1)C(F)(F)F

InChI Key InChIKey=MENRRRXHFQYXDW-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 25436   

TargetAndrogen receptor(Human)
Pfizer

LigandPNGBDBM25436(PF-0998425 | 4-[(1R,2R)-2-hydroxycyclohexyl]-2-(tr...)
Affinity DataIC50: 37nMpH: 7.4 T: 2°CAssay Description:The competitive radio-ligand binding analysis was performed on human AR extracts from transfected Sf9 cells in the presence or absence of differing c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2008
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Pfizer

LigandPNGBDBM25436(PF-0998425 | 4-[(1R,2R)-2-hydroxycyclohexyl]-2-(tr...)
Affinity DataIC50: 26nMAssay Description:Binding affinity to human Androgen receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetAndrogen receptor(Human)
Pfizer

LigandPNGBDBM25436(PF-0998425 | 4-[(1R,2R)-2-hydroxycyclohexyl]-2-(tr...)
Affinity DataIC50: 90nMAssay Description:Antagonist activity at Androgen receptor in human MDA-kb2 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed