BDBM254405 US10112937, Example 313::US10150765, Example 313::US10703749, Example 313::US9464084, 313

SMILES Fc1ccc(nc1)-n1cnc2CN(CCc12)C(=O)c1ccc(Cl)cc1Cl

InChI Key InChIKey=DJIJTCUGJYMPTQ-UHFFFAOYSA-N

Data  12 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 254405   

TargetP2X purinoceptor 7(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM254405(US9464084, 313 | US10112937, Example 313 | US10150...)
Affinity DataIC50: 880nMAssay Description:Antagonist activity at recombinant human P2X7 receptor expressed in human 1321N1 cells assessed as inhibition of Bz-ATP-induced Ca2+ flux preincubate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2018
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM254405(US9464084, 313 | US10112937, Example 313 | US10150...)
Affinity DataIC50: 880nMpH: 7.4Assay Description:1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2019
Entry Details
US Patent

TargetP2X purinoceptor 7(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM254405(US9464084, 313 | US10112937, Example 313 | US10150...)
Affinity DataIC50: 1.11E+3nMpH: 7.4Assay Description:1321 N1 cells expressing the recombinant human, rat or mouse P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2017
Entry Details
US Patent

TargetP2X purinoceptor 7(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM254405(US9464084, 313 | US10112937, Example 313 | US10150...)
Affinity DataIC50: 1.11E+3nMAssay Description:1321N1 cells expressing the recombinant human, rat or mouse P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2019
Entry Details
US Patent

TargetP2X purinoceptor 7(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM254405(US9464084, 313 | US10112937, Example 313 | US10150...)
Affinity DataIC50: 1.11E+3nMpH: 7.4Assay Description:1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2019
Entry Details
US Patent

TargetP2X purinoceptor 7(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM254405(US9464084, 313 | US10112937, Example 313 | US10150...)
Affinity DataIC50: 1.11E+3nMAssay Description:Human or rat P2X7-1321 N1 cells were collected and frozen @−80° C. On the day of the experiment, cell membrane preparations were made according...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2021
Entry Details
US Patent

TargetP2X purinoceptor 7(Rat)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM254405(US9464084, 313 | US10112937, Example 313 | US10150...)
Affinity DataIC50: 1.00E+4nMAssay Description:Antagonist activity at recombinant rat P2X7 receptor expressed in human 1321N1 cells assessed as inhibition of Bz-ATP-induced Ca2+ flux preincubated ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2018
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Rat)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM254405(US9464084, 313 | US10112937, Example 313 | US10150...)
Affinity DataIC50: 2.47E+4nMAssay Description:1321N1 cells expressing the recombinant human, rat or mouse P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2019
Entry Details
US Patent

TargetP2X purinoceptor 7(Rat)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM254405(US9464084, 313 | US10112937, Example 313 | US10150...)
Affinity DataIC50: 2.47E+4nMpH: 7.4Assay Description:1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2019
Entry Details
US Patent

TargetP2X purinoceptor 7(Rat)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM254405(US9464084, 313 | US10112937, Example 313 | US10150...)
Affinity DataIC50: 2.47E+4nMAssay Description:Human or rat P2X7-1321 N1 cells were collected and frozen @−80° C. On the day of the experiment, cell membrane preparations were made according...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2021
Entry Details
US Patent

TargetP2X purinoceptor 7(Rat)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM254405(US9464084, 313 | US10112937, Example 313 | US10150...)
Affinity DataIC50: 2.47E+4nMpH: 7.4Assay Description:1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2019
Entry Details
US Patent

TargetP2X purinoceptor 7(Rat)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM254405(US9464084, 313 | US10112937, Example 313 | US10150...)
Affinity DataIC50: 2.47E+4nMpH: 7.4Assay Description:1321 N1 cells expressing the recombinant human, rat or mouse P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2017
Entry Details
US Patent