BDBM255517 N2,N4-Bis(3-aminophenyl)-5-fluoro-2,4-pyrimidinediamine::US9499493, R921302

SMILES Nc1cccc(c1)N(c1cccc(N)c1)c1ncc(F)c(n1)N(c1cccc(N)c1)c1cccc(N)c1

InChI Key InChIKey=OTEFSAHVJZWOHQ-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 255517   

TargetTyrosine-protein kinase SYK(Human)
Rigel Pharmaceuticals

US Patent
LigandPNGBDBM255517(N2,N4-Bis(3-aminophenyl)-5-fluoro-2,4-pyrimidinedi...)
Affinity DataIC50: 268nMpH: 7.4 T: 2°CAssay Description:Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...More data for this Ligand-Target Pair
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Date in BDB:
10/23/2017
Entry Details
Go to US Patent