BDBM255518 (+/-)-5-Fluoro-N2-[(N-methyl acetamido-2)-3-phenoxy]-N4-(2-methyl-1,4-benzoxazin-6-yl)-2,4-pyrimidinediamine::US9499493, R908712

SMILES COC1=CCCC(Nc2ncc(F)c(Nc3ccc4OC(C)CNc4c3)n2)=C1NC(C)=O

InChI Key InChIKey=GLLYGWFHJSKBBU-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 255518   

TargetTyrosine-protein kinase SYK(Human)
Rigel Pharmaceuticals

US Patent
LigandPNGBDBM255518((+/-)-5-Fluoro-N2-[(N-methyl acetamido-2)-3-phenox...)
Affinity DataIC50: 24nMpH: 7.4 T: 2°CAssay Description:Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2017
Entry Details
Go to US Patent