BDBM255522 5-Fluoro-N4-[(1H)-indol-5-yl]-N2-[3-[(N-methylamino) carbonylmethyleneoxy]phenyl]-2,4-pyrimidinediamine::US9499493, R926931

SMILES CNC(=O)COC1=C(C)CCC(Nc2ncc(F)c(Nc3ccc4[nH]ccc4c3)n2)=C1

InChI Key InChIKey=KARBPZJQEHFIGJ-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 255522   

TargetTyrosine-protein kinase SYK(Human)
Rigel Pharmaceuticals

US Patent
LigandPNGBDBM255522(5-Fluoro-N4-[(1H)-indol-5-yl]-N2-[3-[(N-methylamin...)
Affinity DataIC50: 255nMpH: 7.4 T: 2°CAssay Description:Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...More data for this Ligand-Target Pair
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Date in BDB:
10/23/2017
Entry Details
Go to US Patent