BDBM256500 BDBM256501::US9505743, 44

SMILES Cc1cc(CNC(=O)c2cc(ncn2)C(=O)NCc2ccc(cc2)C(O)=O)ccc1F

InChI Key InChIKey=LXZKIXQSLYEDMA-UHFFFAOYSA-N

Data  12 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 256500   

TargetCollagenase 3(Human)
TBA

US Patent
LigandPNGBDBM256500(BDBM256501 | US9505743, 44)
Affinity DataIC50: 100nMpH: 7.6 T: 2°CAssay Description:MMP-13 inhibitor activity of the MMP inhibitors of the present invention was measured using the method of Knight (Knight, C. G. et. al, FEBS LETT. 29...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2017
Entry Details
Go to US Patent

TargetCollagenase 3(Human)
TBA

US Patent
LigandPNGBDBM256500(BDBM256501 | US9505743, 44)
Affinity DataIC50: 100nMpH: 7.6 T: 2°CAssay Description:MMP-13 inhibitor activity of the MMP inhibitors of the present invention was measured using the method of Knight (Knight, C. G. et. al, FEBS LETT. 29...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2017
Entry Details
Go to US Patent

TargetMacrophage metalloelastase(Human)
Bolderbiopath

Curated by ChEMBL
LigandPNGBDBM256500(BDBM256501 | US9505743, 44)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of recombinant human MMP12 using QXL520-gamma-Abu-Pro-Cha-Abu-Smc-His-Ala-Dab(5-FAM)-Ala-Lys-NH2 as substrate measured every 5 mins for 2 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetStromelysin-2(Human)
Bolderbiopath

Curated by ChEMBL
LigandPNGBDBM256500(BDBM256501 | US9505743, 44)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of recombinant human MMP10 using QXL520-gamma-Abu-Pro-Cha-Abu-Smc-His-Ala-Dab(5-FAM)-Ala-Lys-NH2 as substrate measured every 5 mins for 2 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetMatrix metalloproteinase-9(Human)
Bolderbiopath

Curated by ChEMBL
LigandPNGBDBM256500(BDBM256501 | US9505743, 44)
Affinity DataIC50: 7.40E+4nMAssay Description:Inhibition of recombinant human MMP9 using QXL520-gamma-Abu-Pro-Cha-Abu-Smc-His-Ala-Dab(5-FAM)-Ala-Lys-NH2 as substrate measured every 5 mins for 2 h...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetNeutrophil collagenase(Human)
Bolderbiopath

Curated by ChEMBL
LigandPNGBDBM256500(BDBM256501 | US9505743, 44)
Affinity DataIC50: 9.80E+4nMAssay Description:Inhibition of recombinant human MMP8 using QXL520-gamma-Abu-Pro-Cha-Abu-Smc-His-Ala-Dab(5-FAM)-Ala-Lys-NH2 as substrate measured every 5 mins for 2 h...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetMatrilysin(Human)
Bolderbiopath

Curated by ChEMBL
LigandPNGBDBM256500(BDBM256501 | US9505743, 44)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of recombinant human MMP7 using QXL520-gamma-Abu-Pro-Cha-Abu-Smc-His-Ala-Dab(5-FAM)-Ala-Lys-NH2 as substrate measured every 5 mins for 2 h...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetStromelysin-1(Human)
Bolderbiopath

Curated by ChEMBL
LigandPNGBDBM256500(BDBM256501 | US9505743, 44)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of recombinant human MMP3 using QXL520-gamma-Abu-Pro-Cha-Abu-Smc-His-Ala-Dab(5-FAM)-Ala-Lys-NH2 as substrate measured every 5 mins for 2 h...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Bolderbiopath

Curated by ChEMBL
LigandPNGBDBM256500(BDBM256501 | US9505743, 44)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of recombinant human MMP2 using QXL520-gamma-Abu-Pro-Cha-Abu-Smc-His-Ala-Dab(5-FAM)-Ala-Lys-NH2 as substrate measured every 5 mins for 2 h...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Bolderbiopath

Curated by ChEMBL
LigandPNGBDBM256500(BDBM256501 | US9505743, 44)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of recombinant human MMP1 using QXL520-gamma-Abu-Pro-Cha-Abu-Smc-His-Ala-Dab(5-FAM)-Ala-Lys-NH2 as substrate measured every 5 mins for 2 h...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetCollagenase 3(Human)
TBA

US Patent
LigandPNGBDBM256500(BDBM256501 | US9505743, 44)
Affinity DataIC50: 4.80nMAssay Description:Inhibition of recombinant human MMP13 using QXL520-gamma-Abu-Pro-Cha-Abu-Smc-His-Ala-Dab(5-FAM)-Ala-Lys-NH2 as substrate measured every 5 mins for 2 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetMatrix metalloproteinase-14(Human)
Bolderbiopath

Curated by ChEMBL
LigandPNGBDBM256500(BDBM256501 | US9505743, 44)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of recombinant human MMP14 using QXL520-gamma-Abu-Pro-Cha-Abu-Smc-His-Ala-Dab(5-FAM)-Ala-Lys-NH2 as substrate measured every 5 mins for 2 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed