BDBM256508 US9481648, 6

SMILES COc1cc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(cc(NS(C)(=O)=O)c4OC)C(C)(C)C)c4ccccc34)n2)cc(c1)C(=O)NCCN1CCOCC1

InChI Key InChIKey=PNYZVGKTHJXNGD-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 256508   

TargetProto-oncogene tyrosine-protein kinase Src(Human)
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US Patent
LigandPNGBDBM256508(US9481648, 6)
Affinity DataIC50: 11nMAssay Description:The inhibitory activities of compounds of the invention against c-Src and Syk enzymes (Invitrogen), are evaluated in a similar fashion to that descri...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2017
Entry Details
US Patent

TargetMitogen-activated protein kinase 14(Human)
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US Patent
LigandPNGBDBM256508(US9481648, 6)
Affinity DataIC50: 34nMAssay Description:Method 2: This method follows the same steps as Method 1 above, but utilises a higher concentration of the p38 MAPKα protein (2.5 uL of 200 ng/...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2017
Entry Details
US Patent

TargetTyrosine-protein kinase SYK(Human)
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US Patent
LigandPNGBDBM256508(US9481648, 6)
Affinity DataIC50: 421nMAssay Description:The inhibitory activities of compounds of the invention against c-Src and Syk enzymes (Invitrogen), are evaluated in a similar fashion to that descri...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2017
Entry Details
US Patent

TargetGlycogen synthase kinase-3 alpha(Human)
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US Patent
LigandPNGBDBM256508(US9481648, 6)
Affinity DataIC50: 541nMAssay Description:Method 2: This method follows the same steps as Method 1 above, but utilises a shorter period of mixing of the test compound (105 minutes instead of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2017
Entry Details
US Patent