BDBM256528 US9481648, 27

SMILES COc1cc(Nc2cc(Oc3ccc(NC(=O)Nc4cc(cc(NS(C)(=O)=O)c4OC)C(C)(C)C)c4ccccc34)ccn2)cc(c1)C(=O)NCCN1CCOCC1

InChI Key InChIKey=BHNGTBAKKDCSHZ-UHFFFAOYSA-N

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 256528   

TargetProto-oncogene tyrosine-protein kinase Src(Human)
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US Patent
LigandPNGBDBM256528(US9481648, 27)
Affinity DataIC50: 26nMAssay Description:The inhibitory activities of compounds of the invention against c-Src and Syk enzymes (Invitrogen), are evaluated in a similar fashion to that descri...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2017
Entry Details
US Patent

TargetMitogen-activated protein kinase 14(Human)
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US Patent
LigandPNGBDBM256528(US9481648, 27)
Affinity DataIC50: 41nMAssay Description:Method 2: This method follows the same steps as Method 1 above, but utilises a higher concentration of the p38 MAPKα protein (2.5 uL of 200 ng/...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2017
Entry Details
US Patent

TargetTyrosine-protein kinase SYK(Human)
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US Patent
LigandPNGBDBM256528(US9481648, 27)
Affinity DataIC50: 443nMAssay Description:The inhibitory activities of compounds of the invention against c-Src and Syk enzymes (Invitrogen), are evaluated in a similar fashion to that descri...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2017
Entry Details
US Patent

LigandPNGBDBM256528(US9481648, 27)
Affinity DataIC50: 3.00E+3nMAssay Description:Compounds of the invention were tested for inhibition of the human ether a go-go (hERG) channel using IonWorks patch clamp electrophysiology at Essen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2017
Entry Details
US Patent

TargetGlycogen synthase kinase-3 alpha(Human)
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US Patent
LigandPNGBDBM256528(US9481648, 27)
Affinity DataIC50: 4.50E+3nMAssay Description:Method 2: This method follows the same steps as Method 1 above, but utilises a shorter period of mixing of the test compound (105 minutes instead of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2017
Entry Details
US Patent

TargetCytochrome P450 3A4(Human)
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US Patent
LigandPNGBDBM256528(US9481648, 27)
Affinity DataIC50: 8.90E+3nMAssay Description:Summary of CYP3A4 inhibition studies for various Compound Examples using 30 min preincubation.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2017
Entry Details
US Patent

TargetCytochrome P450 2C9(Human)
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US Patent
LigandPNGBDBM256528(US9481648, 27)
Affinity DataIC50: 1.30E+4nMAssay Description:Summary of CYP2C9 inhibition studies for various Compound Examples using 30 min preincubation.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2017
Entry Details
US Patent

TargetCytochrome P450 3A4(Human)
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US Patent
LigandPNGBDBM256528(US9481648, 27)
Affinity DataIC50: 1.50E+4nMAssay Description:Summary of CYP3A4 inhibition studies for various Compound Examples using 0 min preincubation.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2017
Entry Details
US Patent

TargetCytochrome P450 2C9(Human)
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US Patent
LigandPNGBDBM256528(US9481648, 27)
Affinity DataIC50: 1.50E+4nMAssay Description:Summary of CYP2C9 inhibition studies for various Compound Examples using 0 min preincubation.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2017
Entry Details
US Patent