BDBM25733 CHEMBL476614::Urea-based compound, 14::methyl 4-[(adamantan-1-ylcarbamoyl)amino]-2-hydroxybenzoate

SMILES COC(=O)c1ccc(NC(=O)NC23CC4CC(CC(C4)C2)C3)cc1O

InChI Key

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 25733   

TargetEpoxide hydrolase B(Mycobacterium tuberculosis (strain CDC 1551 / Oshk...)
University of Alberta

LigandPNGBDBM25733(methyl 4-[(adamantan-1-ylcarbamoyl)amino]-2-hydrox...)
Affinity DataIC50: 30nMpH: 7.0 T: 2°CAssay Description:Enzyme activity was measured by monitoring the appearance of fluorescent product, 6-methoxy-naphthaldehyde (ex@330 nm and em@ 465 nm) on a SpectraMax...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/24/2008
Entry Details Article
PubMed
TargetBifunctional epoxide hydrolase 2(Human)
Department of Entomology and University of California Davis Cancer Center

Curated by ChEMBL
LigandPNGBDBM25733(methyl 4-[(adamantan-1-ylcarbamoyl)amino]-2-hydrox...)
Affinity DataIC50: 2.80nMAssay Description:Inhibition of human soluble epoxide hydrolase by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetBifunctional epoxide hydrolase 2(Human)
Department of Entomology and University of California Davis Cancer Center

Curated by ChEMBL
LigandPNGBDBM25733(methyl 4-[(adamantan-1-ylcarbamoyl)amino]-2-hydrox...)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of human recombinant soluble epoxide hydrolase using CMNPC as substrate after 10 mins by fluorescent assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetBifunctional epoxide hydrolase 2(Human)
Department of Entomology and University of California Davis Cancer Center

Curated by ChEMBL
LigandPNGBDBM25733(methyl 4-[(adamantan-1-ylcarbamoyl)amino]-2-hydrox...)
Affinity DataIC50: 2.80nMAssay Description:Inhibition of human recombinant soluble epoxide hydrolase using CMNPC as substrate assessed as appearance of 6-methoxy-2-naphthaldehyde after 10 mins...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed