BDBM26132 (4-phenylphenyl)boranediol::Phenylboronic Acid, 11::Phenylboronic acid, 23

SMILES OB(O)c1ccc(cc1)-c1ccccc1

InChI Key InChIKey=XPEIJWZLPWNNOK-UHFFFAOYSA-N

Data  3 KI  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 26132   

TargetFatty-acid amide hydrolase 1 [30-579](Rat)
University of Oxford

LigandPNGBDBM26132((4-phenylphenyl)boranediol | Phenylboronic acid, 2...)
Affinity DataIC50: 21nMpH: 7.4 T: 2°CAssay Description:[3H]Ethanolamine produced from [3H]AEA hydrolysis was used to calculate FAAH activity and was measured by scintillation counting of the aqueous phase...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2008
Entry Details Article
PubMed
TargetMonoglyceride lipase(Human)
University of Oxford

LigandPNGBDBM26132((4-phenylphenyl)boranediol | Phenylboronic acid, 2...)
Affinity DataIC50: 1.90E+4nMAssay Description:[3H]Ethanolamine produced from [3H]AEA hydrolysis was used to calculate FAAH activity and was measured by scintillation counting of the aqueous phase...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2008
Entry Details Article
PubMed
TargetAcyl-protein thioesterase 1(Human)
Technical University of Dortmund

LigandPNGBDBM26132((4-phenylphenyl)boranediol | Phenylboronic acid, 2...)
Affinity DataIC50: 1.69E+4nMAssay Description:The enzyme activities were determined by measuring the release of fluorescent 6,8-difluoro-4-methylumbelliferone (DiFMU) by the APT hydrolysis of DiF...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2013
Entry Details Article
PubMed
TargetAcyl-protein thioesterase 2(Human)
Technical University of Dortmund

LigandPNGBDBM26132((4-phenylphenyl)boranediol | Phenylboronic acid, 2...)
Affinity DataIC50: 3.55E+3nMAssay Description:The enzyme activities were determined by measuring the release of fluorescent 6,8-difluoro-4-methylumbelliferone (DiFMU) by the APT hydrolysis of DiF...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2013
Entry Details Article
PubMed
TargetFatty-acid amide hydrolase 1 [30-579](Rat)
University of Oxford

LigandPNGBDBM26132((4-phenylphenyl)boranediol | Phenylboronic acid, 2...)
Affinity DataIC50: 790nMAssay Description:Inhibition of rat brain FAAH assessed as hydrolysis of [14C]AEA to [14C]Ethanolamine incubated for 30 mins by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2017
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily V member 1(Human)
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM26132((4-phenylphenyl)boranediol | Phenylboronic acid, 2...)
Affinity DataIC50: 1.00E+4nMAssay Description:Antagonist activity at recombinant human TRPV1 channel expressed in HEK293 cells assessed as inhibition of capsiacin-induced Ca2+ flux preincubated f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2017
Entry Details Article
PubMed
TargetCarbonic anhydrase 1(Human)
Universita Degli Studi Di Firenze

Curated by ChEMBL
LigandPNGBDBM26132((4-phenylphenyl)boranediol | Phenylboronic acid, 2...)
Affinity DataKi:  3.70E+3nMAssay Description:Inhibition of human recombinant cytosolic carbonic anhydrase 1 preincubated for 15 mins by CO2 hydration stopped-flow assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Human)
Universita Degli Studi Di Firenze

Curated by ChEMBL
LigandPNGBDBM26132((4-phenylphenyl)boranediol | Phenylboronic acid, 2...)
Affinity DataKi:  4.50E+3nMAssay Description:Inhibition of human recombinant cytosolic carbonic anhydrase 2 preincubated for 15 mins by CO2 hydration stopped-flow assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetCarbonic anhydrase(Yeast)
Universita Degli Studi Di Firenze

Curated by ChEMBL
LigandPNGBDBM26132((4-phenylphenyl)boranediol | Phenylboronic acid, 2...)
Affinity DataKi:  7.80E+3nMAssay Description:Inhibition of Candida albicans recombinant Carbonic anhydrase pre-incubated for 15 mins by CO2 hydration stopped-flow assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed