BDBM261863 2-(9-Ethyl-9H-carbazol-3-yl)-6-fluoro-1-(2-methoxyethyl)-1H-benzimidazole-5-carboxylic acid::US9708311, 113

SMILES CCn1c2ccccc2c2cc(ccc12)-c1nc2cc(C(O)=O)c(F)cc2n1CCOC

InChI Key InChIKey=GGLRAOVFLKWYNU-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 261863   

TargetProstaglandin E2 receptor EP4 subtype(Human)
Bayer

Curated by ChEMBL
LigandPNGBDBM261863(2-(9-Ethyl-9H-carbazol-3-yl)-6-fluoro-1-(2-methoxy...)
Affinity DataIC50: 35nMAssay Description:Antagonist activity at human EP4R assessed as inhibition of agonist-induced cAMP production by fluorescent cAMP tracer cAMP-d2 based FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetProstaglandin E2 receptor EP4 subtype(Human)
Bayer

Curated by ChEMBL
LigandPNGBDBM261863(2-(9-Ethyl-9H-carbazol-3-yl)-6-fluoro-1-(2-methoxy...)
Affinity DataIC50: 59.5nMT: 2°CAssay Description:4 μl of a cAMP-d2/cell suspension (625000 cells/ml) were added to a test plate containing the substance solutions already initially introduced (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2018
Entry Details
US Patent