BDBM262027 1-(5-(3-(2,6-difluoro-3,5-dimethoxyphenyl)-2-oxo-1-(pyrimidin-4-yl)-1,2,3,4-tetrahydropyrido[4,3-d]pyrimidin-7-yl)pyridin-2-yl)cyclobutanecarbonitrile::US10251892, Example 135::US10632126, Example 135::US11173162, Example 135::US9708318, 135

SMILES COc1cc(OC)c(F)c(N2Cc3cnc(cc3N(C2=O)c2ccncn2)-c2ccc(nc2)C2(CCC2)C#N)c1F

InChI Key InChIKey=JRXRCNFDHYHXEN-UHFFFAOYSA-N

Data  16 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 16 hits for monomerid = 262027   

TargetFibroblast growth factor receptor 3(Human)
Incyte

US Patent

LigandBDBM262027(1-(5-(3-(2,6-difluoro-3,5-dimethoxyphenyl)-2-oxo-1...)Copy SMILESCopy InChI

Affinity DataIC50: 10nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair

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Date in BDB:
1/21/2020
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TargetFibroblast growth factor receptor 2(Human)
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US Patent

LigandBDBM262027(1-(5-(3-(2,6-difluoro-3,5-dimethoxyphenyl)-2-oxo-1...)Copy SMILESCopy InChI

Affinity DataIC50: 10nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair

Target InfoPDBKEGG
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Date in BDB:
1/21/2020
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TargetFibroblast growth factor receptor 3(Human)
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US Patent

LigandBDBM262027(1-(5-(3-(2,6-difluoro-3,5-dimethoxyphenyl)-2-oxo-1...)Copy SMILESCopy InChI

Affinity DataIC50: 10nMAssay Description:FGFR1, FGFR2, and FGFR4 are measured under equivalent conditions with the following changes in enzyme and ATP concentrations: FGFR1, 0.02 nM and 210 ...More data for this Ligand-Target Pair

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Date in BDB:
10/31/2018
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TargetFibroblast growth factor receptor 2(Human)
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US Patent

LigandBDBM262027(1-(5-(3-(2,6-difluoro-3,5-dimethoxyphenyl)-2-oxo-1...)Copy SMILESCopy InChI

Affinity DataIC50: 10nMAssay Description:FGFR1, FGFR2, and FGFR4 are measured under equivalent conditions with the following changes in enzyme and ATP concentrations: FGFR1, 0.02 nM and 210 ...More data for this Ligand-Target Pair

Target InfoPDBKEGG
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Date in BDB:
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TargetFibroblast growth factor receptor 2(Human)
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US Patent

LigandBDBM262027(1-(5-(3-(2,6-difluoro-3,5-dimethoxyphenyl)-2-oxo-1...)Copy SMILESCopy InChI

Affinity DataIC50: 10nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
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Ligand InfoPC cidPC sidSimilars

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Date in BDB:
1/10/2021
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TargetFibroblast growth factor receptor 2(Human)
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US Patent

LigandBDBM262027(1-(5-(3-(2,6-difluoro-3,5-dimethoxyphenyl)-2-oxo-1...)Copy SMILESCopy InChI

Affinity DataIC50: 10nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
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Ligand InfoPC cidPC sidSimilars

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Date in BDB:
4/3/2022
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TargetFibroblast growth factor receptor 3(Human)
Incyte

US Patent

LigandBDBM262027(1-(5-(3-(2,6-difluoro-3,5-dimethoxyphenyl)-2-oxo-1...)Copy SMILESCopy InChI

Affinity DataIC50: 10nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
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Ligand InfoPC cidPC sidSimilars

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Date in BDB:
4/3/2022
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TargetFibroblast growth factor receptor 3(Human)
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US Patent

LigandBDBM262027(1-(5-(3-(2,6-difluoro-3,5-dimethoxyphenyl)-2-oxo-1...)Copy SMILESCopy InChI

Affinity DataIC50: 10nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
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Ligand InfoPC cidPC sidSimilars

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Date in BDB:
1/10/2021
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TargetFibroblast growth factor receptor 1(Human)
Incyte

US Patent

LigandBDBM262027(1-(5-(3-(2,6-difluoro-3,5-dimethoxyphenyl)-2-oxo-1...)Copy SMILESCopy InChI

Affinity DataIC50: 115nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
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Ligand InfoPC cidPC sidSimilars

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Date in BDB:
1/21/2020
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TargetFibroblast growth factor receptor 4(Human)
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US Patent

LigandBDBM262027(1-(5-(3-(2,6-difluoro-3,5-dimethoxyphenyl)-2-oxo-1...)Copy SMILESCopy InChI

Affinity DataIC50: 115nMAssay Description:FGFR1, FGFR2, and FGFR4 are measured under equivalent conditions with the following changes in enzyme and ATP concentrations: FGFR1, 0.02 nM and 210 ...More data for this Ligand-Target Pair

Target InfoPDBKEGG
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Ligand InfoPC cidPC sidSimilars

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Date in BDB:
10/31/2018
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TargetFibroblast growth factor receptor 4(Human)
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LigandBDBM262027(1-(5-(3-(2,6-difluoro-3,5-dimethoxyphenyl)-2-oxo-1...)Copy SMILESCopy InChI

Affinity DataIC50: 115nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
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Date in BDB:
1/21/2020
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TargetFibroblast growth factor receptor 1(Human)
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US Patent

LigandBDBM262027(1-(5-(3-(2,6-difluoro-3,5-dimethoxyphenyl)-2-oxo-1...)Copy SMILESCopy InChI

Affinity DataIC50: 115nMAssay Description:FGFR1, FGFR2, and FGFR4 are measured under equivalent conditions with the following changes in enzyme and ATP concentrations: FGFR1, 0.02 nM and 210 ...More data for this Ligand-Target Pair

Target InfoPDBKEGG
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Ligand InfoPC cidPC sidSimilars

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Date in BDB:
10/31/2018
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TargetFibroblast growth factor receptor 1(Human)
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US Patent

LigandBDBM262027(1-(5-(3-(2,6-difluoro-3,5-dimethoxyphenyl)-2-oxo-1...)Copy SMILESCopy InChI

Affinity DataIC50: 115nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
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Ligand InfoPC cidPC sidSimilars

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Date in BDB:
4/3/2022
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TargetFibroblast growth factor receptor 1(Human)
Incyte

US Patent

LigandBDBM262027(1-(5-(3-(2,6-difluoro-3,5-dimethoxyphenyl)-2-oxo-1...)Copy SMILESCopy InChI

Affinity DataIC50: 115nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
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Ligand InfoPC cidPC sidSimilars

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Date in BDB:
1/10/2021
Entry Details
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TargetFibroblast growth factor receptor 4(Human)
Incyte

US Patent

LigandBDBM262027(1-(5-(3-(2,6-difluoro-3,5-dimethoxyphenyl)-2-oxo-1...)Copy SMILESCopy InChI

Affinity DataIC50: 115nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
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Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
1/10/2021
Entry Details
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TargetFibroblast growth factor receptor 4(Human)
Incyte

US Patent

LigandBDBM262027(1-(5-(3-(2,6-difluoro-3,5-dimethoxyphenyl)-2-oxo-1...)Copy SMILESCopy InChI

Affinity DataIC50: 115nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
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Ligand InfoPC cidPC sidSimilars

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Date in BDB:
4/3/2022
Entry Details
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