BDBM262052 3-(2,6-difluoro-3,5- dimethoxyphenyl)-7-(1,3-dimethyl- 1H-pyrazol-4-yl)-1-ethyl-3,4- dihydropyrido[4,3-d]pyrimidin-2(1H)- one::US10251892, Example 170::US10632126, Example 170::US11173162, Example 170::US9708318, 170

SMILES CCN1C(=O)N(Cc2cnc(cc12)-c1cn(C)nc1C)c1c(F)c(OC)cc(OC)c1F

InChI Key InChIKey=PZCXYKOZZLAULJ-UHFFFAOYSA-N

Data  28 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 28 hits for monomerid = 262052   

TargetFibroblast growth factor receptor 2(Human)
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LigandBDBM262052(3-(2,6-difluoro-3,5- dimethoxyphenyl)-7-(1,3-dimet...)Copy SMILESCopy InChI

Affinity DataIC50: 10nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair

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Date in BDB:
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TargetFibroblast growth factor receptor 3(Human)
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LigandBDBM262052(3-(2,6-difluoro-3,5- dimethoxyphenyl)-7-(1,3-dimet...)Copy SMILESCopy InChI

Affinity DataIC50: 10nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair

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Date in BDB:
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TargetFibroblast growth factor receptor 3(Human)
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LigandBDBM262052(3-(2,6-difluoro-3,5- dimethoxyphenyl)-7-(1,3-dimet...)Copy SMILESCopy InChI

Affinity DataIC50: 10nMAssay Description:FGFR1, FGFR2, and FGFR4 are measured under equivalent conditions with the following changes in enzyme and ATP concentrations: FGFR1, 0.02 nM and 210 ...More data for this Ligand-Target Pair

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Date in BDB:
10/31/2018
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TargetFibroblast growth factor receptor 2(Human)
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LigandBDBM262052(3-(2,6-difluoro-3,5- dimethoxyphenyl)-7-(1,3-dimet...)Copy SMILESCopy InChI

Affinity DataIC50: 10nMAssay Description:FGFR1, FGFR2, and FGFR4 are measured under equivalent conditions with the following changes in enzyme and ATP concentrations: FGFR1, 0.02 nM and 210 ...More data for this Ligand-Target Pair

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Date in BDB:
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TargetFibroblast growth factor receptor 3(Human)
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LigandBDBM262052(3-(2,6-difluoro-3,5- dimethoxyphenyl)-7-(1,3-dimet...)Copy SMILESCopy InChI

Affinity DataIC50: 10nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair

Target InfoPDBKEGG
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Date in BDB:
1/21/2020
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TargetFibroblast growth factor receptor 2(Human)
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LigandBDBM262052(3-(2,6-difluoro-3,5- dimethoxyphenyl)-7-(1,3-dimet...)Copy SMILESCopy InChI

Affinity DataIC50: 10nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair

Target InfoPDBKEGG
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TargetFibroblast growth factor receptor 2(Human)
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LigandBDBM262052(3-(2,6-difluoro-3,5- dimethoxyphenyl)-7-(1,3-dimet...)Copy SMILESCopy InChI

Affinity DataIC50: 10nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
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Date in BDB:
1/10/2021
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TargetFibroblast growth factor receptor 3(Human)
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LigandBDBM262052(3-(2,6-difluoro-3,5- dimethoxyphenyl)-7-(1,3-dimet...)Copy SMILESCopy InChI

Affinity DataIC50: 10nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair

Target InfoPDBKEGG
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1/10/2021
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TargetFibroblast growth factor receptor 2(Human)
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LigandBDBM262052(3-(2,6-difluoro-3,5- dimethoxyphenyl)-7-(1,3-dimet...)Copy SMILESCopy InChI

Affinity DataIC50: 10nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
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Date in BDB:
4/3/2022
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TargetFibroblast growth factor receptor 3(Human)
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LigandBDBM262052(3-(2,6-difluoro-3,5- dimethoxyphenyl)-7-(1,3-dimet...)Copy SMILESCopy InChI

Affinity DataIC50: 10nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
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Ligand InfoPC cidPC sidSimilars

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Date in BDB:
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TargetFibroblast growth factor receptor 3(Human)
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LigandBDBM262052(3-(2,6-difluoro-3,5- dimethoxyphenyl)-7-(1,3-dimet...)Copy SMILESCopy InChI

Affinity DataIC50: 10nMAssay Description:FGFR1, FGFR2, and FGFR4 are measured under equivalent conditions with the following changes in enzyme and ATP concentrations: FGFR1, 0.02 nM and 210 ...More data for this Ligand-Target Pair

Target InfoPDBKEGG
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TargetFibroblast growth factor receptor 2(Human)
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LigandBDBM262052(3-(2,6-difluoro-3,5- dimethoxyphenyl)-7-(1,3-dimet...)Copy SMILESCopy InChI

Affinity DataIC50: 10nMAssay Description:FGFR1, FGFR2, and FGFR4 are measured under equivalent conditions with the following changes in enzyme and ATP concentrations: FGFR1, 0.02 nM and 210 ...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
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Ligand InfoPC cidPC sidSimilars

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Date in BDB:
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TargetFibroblast growth factor receptor 3(Human)
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LigandBDBM262052(3-(2,6-difluoro-3,5- dimethoxyphenyl)-7-(1,3-dimet...)Copy SMILESCopy InChI

Affinity DataIC50: 10nMAssay Description:In the FGFR Enzymatic Assay after dilution in assay buffer, added to the plate and pre-incubated for 5 to 10 minutes.More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
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Date in BDB:
1/21/2020
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TargetFibroblast growth factor receptor 2(Human)
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LigandBDBM262052(3-(2,6-difluoro-3,5- dimethoxyphenyl)-7-(1,3-dimet...)Copy SMILESCopy InChI

Affinity DataIC50: 10nMAssay Description:In the FGFR Enzymatic Assay after dilution in assay buffer, added to the plate and pre-incubated for 5 to 10 minutes.More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
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Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
1/21/2020
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TargetFibroblast growth factor receptor 4(Human)
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US Patent

LigandBDBM262052(3-(2,6-difluoro-3,5- dimethoxyphenyl)-7-(1,3-dimet...)Copy SMILESCopy InChI

Affinity DataIC50: 20nMAssay Description:FGFR1, FGFR2, and FGFR4 are measured under equivalent conditions with the following changes in enzyme and ATP concentrations: FGFR1, 0.02 nM and 210 ...More data for this Ligand-Target Pair

Target InfoPDBKEGG
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Ligand InfoPC cidPC sidSimilars

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Date in BDB:
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TargetFibroblast growth factor receptor 4(Human)
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LigandBDBM262052(3-(2,6-difluoro-3,5- dimethoxyphenyl)-7-(1,3-dimet...)Copy SMILESCopy InChI

Affinity DataIC50: 20nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
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Ligand InfoPC cidPC sidSimilars

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Date in BDB:
4/3/2022
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TargetFibroblast growth factor receptor 1(Human)
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LigandBDBM262052(3-(2,6-difluoro-3,5- dimethoxyphenyl)-7-(1,3-dimet...)Copy SMILESCopy InChI

Affinity DataIC50: 20nMAssay Description:FGFR1, FGFR2, and FGFR4 are measured under equivalent conditions with the following changes in enzyme and ATP concentrations: FGFR1, 0.02 nM and 210 ...More data for this Ligand-Target Pair

Target InfoPDBKEGG
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Ligand InfoPC cidPC sidSimilars

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Date in BDB:
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TargetFibroblast growth factor receptor 1(Human)
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LigandBDBM262052(3-(2,6-difluoro-3,5- dimethoxyphenyl)-7-(1,3-dimet...)Copy SMILESCopy InChI

Affinity DataIC50: 20nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
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Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
1/21/2020
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TargetFibroblast growth factor receptor 1(Human)
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LigandBDBM262052(3-(2,6-difluoro-3,5- dimethoxyphenyl)-7-(1,3-dimet...)Copy SMILESCopy InChI

Affinity DataIC50: 20nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
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Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
1/10/2021
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TargetFibroblast growth factor receptor 4(Human)
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LigandBDBM262052(3-(2,6-difluoro-3,5- dimethoxyphenyl)-7-(1,3-dimet...)Copy SMILESCopy InChI

Affinity DataIC50: 20nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
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Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
1/10/2021
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TargetFibroblast growth factor receptor 4(Human)
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LigandBDBM262052(3-(2,6-difluoro-3,5- dimethoxyphenyl)-7-(1,3-dimet...)Copy SMILESCopy InChI

Affinity DataIC50: 20nMAssay Description:In the FGFR Enzymatic Assay after dilution in assay buffer, added to the plate and pre-incubated for 5 to 10 minutes.More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
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Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
1/21/2020
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TargetFibroblast growth factor receptor 1(Human)
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LigandBDBM262052(3-(2,6-difluoro-3,5- dimethoxyphenyl)-7-(1,3-dimet...)Copy SMILESCopy InChI

Affinity DataIC50: 20nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
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Ligand InfoPC cidPC sidSimilars

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Date in BDB:
4/3/2022
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TargetFibroblast growth factor receptor 4(Human)
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LigandBDBM262052(3-(2,6-difluoro-3,5- dimethoxyphenyl)-7-(1,3-dimet...)Copy SMILESCopy InChI

Affinity DataIC50: 20nMAssay Description:FGFR1, FGFR2, and FGFR4 are measured under equivalent conditions with the following changes in enzyme and ATP concentrations: FGFR1, 0.02 nM and 210 ...More data for this Ligand-Target Pair

Target InfoPDBKEGG
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In Depth
Date in BDB:
10/31/2018
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TargetFibroblast growth factor receptor 4(Human)
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LigandBDBM262052(3-(2,6-difluoro-3,5- dimethoxyphenyl)-7-(1,3-dimet...)Copy SMILESCopy InChI

Affinity DataIC50: 20nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
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Date in BDB:
4/3/2022
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TargetFibroblast growth factor receptor 1(Human)
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LigandBDBM262052(3-(2,6-difluoro-3,5- dimethoxyphenyl)-7-(1,3-dimet...)Copy SMILESCopy InChI

Affinity DataIC50: 20nMAssay Description:FGFR1, FGFR2, and FGFR4 are measured under equivalent conditions with the following changes in enzyme and ATP concentrations: FGFR1, 0.02 nM and 210 ...More data for this Ligand-Target Pair

Target InfoPDBKEGG
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Ligand InfoPC cidPC sidSimilars

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Date in BDB:
10/31/2018
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TargetFibroblast growth factor receptor 1(Human)
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LigandBDBM262052(3-(2,6-difluoro-3,5- dimethoxyphenyl)-7-(1,3-dimet...)Copy SMILESCopy InChI

Affinity DataIC50: 20nMAssay Description:In the FGFR Enzymatic Assay after dilution in assay buffer, added to the plate and pre-incubated for 5 to 10 minutes.More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
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Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
1/21/2020
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TargetFibroblast growth factor receptor 4(Human)
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LigandBDBM262052(3-(2,6-difluoro-3,5- dimethoxyphenyl)-7-(1,3-dimet...)Copy SMILESCopy InChI

Affinity DataIC50: 20nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
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Date in BDB:
1/21/2020
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TargetFibroblast growth factor receptor 1(Human)
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LigandBDBM262052(3-(2,6-difluoro-3,5- dimethoxyphenyl)-7-(1,3-dimet...)Copy SMILESCopy InChI

Affinity DataIC50: 20nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
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Ligand InfoPC cidPC sidSimilars

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Date in BDB:
4/3/2022
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