BDBM262089 3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-((1-ethyl-1H-pyrazol-4-yl)methyl)-7-(1-methyl-1H-pyrazol-4-yl)-3,4-dihydropyrido[4,3-d]pyrimidin-2(1H)-one::US10251892, Example 145::US9708318, 145

SMILES CCn1cc(CN2C(=O)N(Cc3cnc(cc23)-c2cnn(C)c2)c2c(F)c(OC)cc(OC)c2F)cn1

InChI Key InChIKey=DAKNCYGLEBYHLQ-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 262089   

TargetFibroblast growth factor receptor 1(Human)
Incyte

US Patent
LigandPNGBDBM262089(3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-((1-ethyl-1...)
Affinity DataIC50: 10nMAssay Description:FGFR1, FGFR2, and FGFR4 are measured under equivalent conditions with the following changes in enzyme and ATP concentrations: FGFR1, 0.02 nM and 210 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2018
Entry Details
US Patent

TargetFibroblast growth factor receptor 3(Human)
Incyte

US Patent
LigandPNGBDBM262089(3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-((1-ethyl-1...)
Affinity DataIC50: 10nMAssay Description:In the FGFR Enzymatic Assay after dilution in assay buffer, added to the plate and pre-incubated for 5 to 10 minutes.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

TargetFibroblast growth factor receptor 2(Human)
Incyte

US Patent
LigandPNGBDBM262089(3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-((1-ethyl-1...)
Affinity DataIC50: 10nMAssay Description:In the FGFR Enzymatic Assay after dilution in assay buffer, added to the plate and pre-incubated for 5 to 10 minutes.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

TargetFibroblast growth factor receptor 1(Human)
Incyte

US Patent
LigandPNGBDBM262089(3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-((1-ethyl-1...)
Affinity DataIC50: 10nMAssay Description:In the FGFR Enzymatic Assay after dilution in assay buffer, added to the plate and pre-incubated for 5 to 10 minutes.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

TargetFibroblast growth factor receptor 3(Human)
Incyte

US Patent
LigandPNGBDBM262089(3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-((1-ethyl-1...)
Affinity DataIC50: 10nMAssay Description:FGFR1, FGFR2, and FGFR4 are measured under equivalent conditions with the following changes in enzyme and ATP concentrations: FGFR1, 0.02 nM and 210 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2018
Entry Details
US Patent

TargetFibroblast growth factor receptor 2(Human)
Incyte

US Patent
LigandPNGBDBM262089(3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-((1-ethyl-1...)
Affinity DataIC50: 10nMAssay Description:FGFR1, FGFR2, and FGFR4 are measured under equivalent conditions with the following changes in enzyme and ATP concentrations: FGFR1, 0.02 nM and 210 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2018
Entry Details
US Patent

TargetFibroblast growth factor receptor 4(Human)
Incyte

US Patent
LigandPNGBDBM262089(3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-((1-ethyl-1...)
Affinity DataIC50: 20nMAssay Description:FGFR1, FGFR2, and FGFR4 are measured under equivalent conditions with the following changes in enzyme and ATP concentrations: FGFR1, 0.02 nM and 210 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2018
Entry Details
US Patent

TargetFibroblast growth factor receptor 4(Human)
Incyte

US Patent
LigandPNGBDBM262089(3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-((1-ethyl-1...)
Affinity DataIC50: 20nMAssay Description:In the FGFR Enzymatic Assay after dilution in assay buffer, added to the plate and pre-incubated for 5 to 10 minutes.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent