BDBM262631 3-(2-Cyanobenzo[d]thiazol-4-yl)-2-(1H-tetrazol-5-yl)-6-(trifluoromethyl)benzenesulfonamide::US9708336, 483

SMILES NS(=O)(=O)c1c(ccc(-c2cccc3sc(nc23)C#N)c1-c1nnn[nH]1)C(F)(F)F

InChI Key InChIKey=CFRDZTYEGFLJAU-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 262631   

TargetVIM-1 metallo-beta-lactamase(Pseudomonas aeruginosa (g-Proteobacteria))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM262631(3-(2-Cyanobenzo[d]thiazol-4-yl)-2-(1H-tetrazol-5-y...)
Affinity DataIC50: 0.216nMpH: 7.0Assay Description:The Class B enzyme activities were measured in the presence of the test inhibitor in a fluorescence assay against a commercially available substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/5/2018
Entry Details
US Patent

TargetMetallo-beta-lactamase type 2(Pseudomonas aeruginosa (g-Proteobacteria))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM262631(3-(2-Cyanobenzo[d]thiazol-4-yl)-2-(1H-tetrazol-5-y...)
Affinity DataIC50: 0.755nMpH: 7.0Assay Description:The Class B enzyme activities were measured in the presence of the test inhibitor in a fluorescence assay against a commercially available substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/5/2018
Entry Details
US Patent

TargetMetallo-beta-lactamase type 2(Serratia marcescens)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM262631(3-(2-Cyanobenzo[d]thiazol-4-yl)-2-(1H-tetrazol-5-y...)
Affinity DataIC50: 2.12nMpH: 7.0Assay Description:The Class B enzyme activities were measured in the presence of the test inhibitor in a fluorescence assay against a commercially available substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/5/2018
Entry Details
US Patent