BDBM262969 9-[3-sulfamoyl-2-(1H-tetrazol-5-yl)- 4-(trifluoromethyl)phenyl]-3,9- diazaspiro[5.5]undecane-3- carboxamidine::US9708336, 822

SMILES NC(=N)N1CCC2(CC1)CCN(CC2)c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)C(F)(F)F

InChI Key InChIKey=OUSYRGFGEKGPNY-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 262969   

TargetVIM-1 metallo-beta-lactamase(Pseudomonas aeruginosa (g-Proteobacteria))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM262969(9-[3-sulfamoyl-2-(1H-tetrazol-5-yl)- 4-(trifluorom...)
Affinity DataIC50: 0.196nMpH: 7.0Assay Description:The Class B enzyme activities were measured in the presence of the test inhibitor in a fluorescence assay against a commercially available substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/5/2018
Entry Details
US Patent

TargetMetallo-beta-lactamase type 2(Pseudomonas aeruginosa (g-Proteobacteria))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM262969(9-[3-sulfamoyl-2-(1H-tetrazol-5-yl)- 4-(trifluorom...)
Affinity DataIC50: 1.44nMpH: 7.0Assay Description:The Class B enzyme activities were measured in the presence of the test inhibitor in a fluorescence assay against a commercially available substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/5/2018
Entry Details
US Patent

TargetMetallo-beta-lactamase type 2(Serratia marcescens)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM262969(9-[3-sulfamoyl-2-(1H-tetrazol-5-yl)- 4-(trifluorom...)
Affinity DataIC50: 2.25nMpH: 7.0Assay Description:The Class B enzyme activities were measured in the presence of the test inhibitor in a fluorescence assay against a commercially available substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/5/2018
Entry Details
US Patent