BDBM26297 CHEMBL215322::N-(2,3-difluorophenyl)-2-{3-[(7-{3-[ethyl(2-hydroxyethyl)amino]propoxy}quinazolin-4-yl)amino]-1H-pyrazol-5-yl}acetamide::pyrazoloquinazoline deriv., 31

SMILES CCN(CCO)CCCOc1ccc2c(Nc3cc(CC(=O)Nc4cccc(F)c4F)n[nH]3)ncnc2c1

InChI Key InChIKey=CNWZWPQCJCOBHA-UHFFFAOYSA-N

Data  2 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 26297   

TargetAurora kinase B(Human)
Astrazeneca

LigandPNGBDBM26297(N-(2,3-difluorophenyl)-2-{3-[(7-{3-[ethyl(2-hydrox...)
Affinity DataKi: <1nM ΔG°: <-12.3kcal/moleT: 2°CAssay Description:In vitro kinase assay using recombinant Aurora B bound to INCENP was incubated at room temperature with substrate, and test compounds in the presence...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2009
Entry Details Article
PubMed
TargetAurora kinase B(Human)
Astrazeneca

LigandPNGBDBM26297(N-(2,3-difluorophenyl)-2-{3-[(7-{3-[ethyl(2-hydrox...)
Affinity DataIC50: 7.5nMAssay Description:Inhibition of aurora B kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2012
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Astrazeneca

LigandPNGBDBM26297(N-(2,3-difluorophenyl)-2-{3-[(7-{3-[ethyl(2-hydrox...)
Affinity DataKi:  160nM ΔG°:  -9.26kcal/moleT: 2°CAssay Description:In vitro kinase assay using recombinant Aurora A purified from Sf9 cells was incubated at room temperature with substrate, and test compounds in the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2009
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Astrazeneca

LigandPNGBDBM26297(N-(2,3-difluorophenyl)-2-{3-[(7-{3-[ethyl(2-hydrox...)
Affinity DataIC50: 800nMAssay Description:Inhibition of aurora A kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2012
Entry Details Article
PubMed