BDBM263449 US9550741, RGH-188

SMILES CN(C)C(=O)NC1CCC(CCN2CCN(CC2)c2cccc(Cl)c2Cl)CC1

InChI Key InChIKey=KPWSJANDNDDRMB-UHFFFAOYSA-N

Data  4 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 263449   

TargetVitamin D3 receptor(Human)
Shanghai Institute of Pharmaceutical Industry

US Patent
LigandPNGBDBM263449(US9550741, RGH-188)
Affinity DataKi:  0.0900nMAssay Description:The experiment is carried out by the method according to Journal of Pharmacology and Experimental Therapeutics 2010, 333(1): 328. With [3H]methyl-spi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2018
Entry Details
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TargetD(2) dopamine receptor(Human)
Shanghai Institute of Pharmaceutical Industry

US Patent
LigandPNGBDBM263449(US9550741, RGH-188)
Affinity DataKi:  0.780nMpH: 7.5Assay Description:1. Experimental Materials:(1) D2 receptor Cell Transfection:This experiment utilizes the plasmid vector containing the gene of D2 receptor protein fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2018
Entry Details
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Target5-hydroxytryptamine receptor 1A(Human)
Shanghai Institute of Pharmaceutical Industry

US Patent
LigandPNGBDBM263449(US9550741, RGH-188)
Affinity DataKi:  2.16nMpH: 7.4Assay Description:1. Experimental Materials:The isotopic ligand of 5-H1A receptor [3H]0.8-OH-DPAT (purchased from PE Corporation), (+)5-hydroxytryptamine (purchased fr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2018
Entry Details
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Target5-hydroxytryptamine receptor 2A(Human)
Shanghai Institute of Pharmaceutical Industry

US Patent
LigandPNGBDBM263449(US9550741, RGH-188)
Affinity DataKi:  20.5nMpH: 7.7Assay Description:1. Experimental Materials(1) 5-HT2A Cell Transfection:This experiment utilizes the plasmid vector containing the gene of the 5-HT2A receptor protein ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2018
Entry Details
Go to US Patent