BDBM26365 3-N-(2-aminopyrimidin-5-yl)-4-methyl-1-N-[3-(trifluoromethyl)phenyl]benzene-1,3-dicarboxamide::Aminopyrimidine amide, 10a::CHEMBL272902

SMILES Cc1ccc(cc1C(=O)Nc1cnc(N)nc1)C(=O)Nc1cccc(c1)C(F)(F)F

InChI Key InChIKey=OSMXTIVEGNMCKM-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 26365   

TargetTyrosine-protein kinase Lck(Human)
Amgen

LigandPNGBDBM26365(CHEMBL272902 | 3-N-(2-aminopyrimidin-5-yl)-4-methy...)
Affinity DataIC50: 15nMpH: 7.5 T: 2°CAssay Description:The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2009
Entry Details Article
PubMed
TargetAngiopoietin-1 receptor(Human)
Amgen

LigandPNGBDBM26365(CHEMBL272902 | 3-N-(2-aminopyrimidin-5-yl)-4-methy...)
Affinity DataIC50: 5.00E+3nMAssay Description:The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2009
Entry Details Article
PubMed
LigandPNGBDBM26365(CHEMBL272902 | 3-N-(2-aminopyrimidin-5-yl)-4-methy...)
Affinity DataIC50: 205nMAssay Description:The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2009
Entry Details Article
PubMed
LigandPNGBDBM26365(CHEMBL272902 | 3-N-(2-aminopyrimidin-5-yl)-4-methy...)
Affinity DataIC50: 87nMAssay Description:The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2009
Entry Details Article
PubMed
LigandPNGBDBM26365(CHEMBL272902 | 3-N-(2-aminopyrimidin-5-yl)-4-methy...)
Affinity DataIC50: 2.50E+4nMAssay Description:The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2009
Entry Details Article
PubMed
LigandPNGBDBM26365(CHEMBL272902 | 3-N-(2-aminopyrimidin-5-yl)-4-methy...)
Affinity DataIC50: 205nMAssay Description:Inhibition of KDRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM26365(CHEMBL272902 | 3-N-(2-aminopyrimidin-5-yl)-4-methy...)
Affinity DataIC50: 87nMAssay Description:Inhibition of p38alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM26365(CHEMBL272902 | 3-N-(2-aminopyrimidin-5-yl)-4-methy...)
Affinity DataIC50: 5nMAssay Description:Inhibition of c-kitMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed