BDBM26368 3-N-(2-aminopyrimidin-5-yl)-4-methyl-1-N-[3-(trifluoromethyl)benzene]benzene-1,3-dicarboxamide::Aminopyrimidine amide, 13a

SMILES Cc1ccc(NC(=O)c2cccc(c2)C(F)(F)F)cc1C(=O)Nc1cnc(N)nc1

InChI Key InChIKey=HZYVHWDHIRWTNY-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 26368   

TargetTyrosine-protein kinase Lck(Human)
Amgen

LigandPNGBDBM26368(3-N-(2-aminopyrimidin-5-yl)-4-methyl-1-N-[3-(trifl...)
Affinity DataIC50: 14nMpH: 7.5 T: 2°CAssay Description:The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2009
Entry Details Article
PubMed
TargetAngiopoietin-1 receptor(Human)
Amgen

LigandPNGBDBM26368(3-N-(2-aminopyrimidin-5-yl)-4-methyl-1-N-[3-(trifl...)
Affinity DataIC50: 2.50E+4nMAssay Description:The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2009
Entry Details Article
PubMed
LigandPNGBDBM26368(3-N-(2-aminopyrimidin-5-yl)-4-methyl-1-N-[3-(trifl...)
Affinity DataIC50: 125nMAssay Description:The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2009
Entry Details Article
PubMed
LigandPNGBDBM26368(3-N-(2-aminopyrimidin-5-yl)-4-methyl-1-N-[3-(trifl...)
Affinity DataIC50: 14nMAssay Description:The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2009
Entry Details Article
PubMed
LigandPNGBDBM26368(3-N-(2-aminopyrimidin-5-yl)-4-methyl-1-N-[3-(trifl...)
Affinity DataIC50: 2.50E+4nMAssay Description:The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2009
Entry Details Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
Peking University

Curated by ChEMBL
LigandPNGBDBM26368(3-N-(2-aminopyrimidin-5-yl)-4-methyl-1-N-[3-(trifl...)
Affinity DataIC50: 3.42E+3nMAssay Description:Inhibition of Btk (unknown origin) after 1 hr by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2015
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Amgen

LigandPNGBDBM26368(3-N-(2-aminopyrimidin-5-yl)-4-methyl-1-N-[3-(trifl...)
Affinity DataIC50: 149nMAssay Description:Inhibition of Lck (unknown origin) after 1 hr by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2015
Entry Details Article
PubMed