BDBM263837 6-[4- (difluoro- methoxy)-2- fluoro- phenyl]-1- fluoro-5-[4- [(3S)-1-(3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]-8,9- dihydro- 7H- benzo[7]- annulen-2-ol::US9714221, Example 165

SMILES Oc1ccc2c(CCCC(c3ccc(OC(F)F)cc3F)=C2c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c1F

InChI Key InChIKey=GQXDOOQZYUMRGG-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 263837   

TargetEstrogen receptor(Human)
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM263837(6-[4- (difluoro- methoxy)-2- fluoro- phenyl]-1- fl...)
Affinity DataIC50: 0.200nMAssay Description:Induction of ERalpha degradation in human MCF7 cells after 4 hrs by in cell western assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/17/2020
Entry Details Article
PubMed
TargetEstrogen receptor(Human)
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM263837(6-[4- (difluoro- methoxy)-2- fluoro- phenyl]-1- fl...)
Affinity DataIC50: 2nMAssay Description:Antagonist activity at recombinant human His6-tagged ERalpha LBD (298 to 554 residues) expressed in Escherichia coli assessed as inhibition of estrad...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/17/2020
Entry Details Article
PubMed
TargetEstrogen receptor(Human)
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM263837(6-[4- (difluoro- methoxy)-2- fluoro- phenyl]-1- fl...)
Affinity DataIC50: 13nMpH: 7.4 T: 2°CAssay Description:It is a competition assay, where binding of a test compound to a complex comprised of (i) His6-ERα298-554 protein representing ERα ligand-b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2018
Entry Details
US Patent

TargetEstrogen receptor(Human)
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM263837(6-[4- (difluoro- methoxy)-2- fluoro- phenyl]-1- fl...)
Affinity DataIC50: 27nMAssay Description:Antagonist activity at recombinant human His6-tagged ERalpha LBD (298 to 554 residues) Y537S mutant expressed in Escherichia coli assessed as inhibit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/17/2020
Entry Details Article
PubMed
TargetEstrogen receptor(Human)
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM263837(6-[4- (difluoro- methoxy)-2- fluoro- phenyl]-1- fl...)
Affinity DataIC50: 47nMAssay Description:Antagonist activity at recombinant human His6-tagged ERalpha LBD (298 to 554 residues) D538G mutant expressed in Escherichia coli assessed as inhibit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/17/2020
Entry Details Article
PubMed
TargetEstrogen receptor [Y537S](Human)
Sanofi

US Patent
LigandPNGBDBM263837(6-[4- (difluoro- methoxy)-2- fluoro- phenyl]-1- fl...)
Affinity DataIC50: 299nMpH: 7.4 T: 2°CAssay Description:It is a competition assay, where binding of a test compound to a complex comprised of (i) His6-ERα298-554 protein representing ERα ligand-b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2018
Entry Details
US Patent

TargetEstrogen receptor [D538G](Human)
Sanofi

US Patent
LigandPNGBDBM263837(6-[4- (difluoro- methoxy)-2- fluoro- phenyl]-1- fl...)
Affinity DataIC50: 560nMpH: 7.4 T: 2°CAssay Description:It is a competition assay, where binding of a test compound to a complex comprised of (i) His6-ERα298-554 protein representing ERα ligand-b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2018
Entry Details
US Patent