BDBM26386 Aminopyrimidine amide, 32::N-{4-chloro-3-[(2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-5-yl)carbamoyl]phenyl}-2,2-difluoro-2H-1,3-benzodioxole-5-carboxamide

SMILES CN1CCN(CC1)c1ccc(Nc2ncc(NC(=O)c3cc(NC(=O)c4ccc5OC(F)(F)Oc5c4)ccc3Cl)cn2)cc1

InChI Key InChIKey=WNUWKJKIAMXFRA-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 26386   

TargetTyrosine-protein kinase Lck(Human)
Amgen

LigandPNGBDBM26386(N-{4-chloro-3-[(2-{[4-(4-methylpiperazin-1-yl)phen...)
Affinity DataIC50: 1.80nMpH: 7.5 T: 2°CAssay Description:The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2009
Entry Details Article
PubMed
LigandPNGBDBM26386(N-{4-chloro-3-[(2-{[4-(4-methylpiperazin-1-yl)phen...)
Affinity DataIC50: 6nMAssay Description:The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2009
Entry Details Article
PubMed
LigandPNGBDBM26386(N-{4-chloro-3-[(2-{[4-(4-methylpiperazin-1-yl)phen...)
Affinity DataIC50: 13nMAssay Description:The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2009
Entry Details Article
PubMed
LigandPNGBDBM26386(N-{4-chloro-3-[(2-{[4-(4-methylpiperazin-1-yl)phen...)
Affinity DataIC50: 5.00E+3nMAssay Description:The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2009
Entry Details Article
PubMed
TargetAngiopoietin-1 receptor(Human)
Amgen

LigandPNGBDBM26386(N-{4-chloro-3-[(2-{[4-(4-methylpiperazin-1-yl)phen...)
Affinity DataIC50: 5.00E+3nMAssay Description:The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2009
Entry Details Article
PubMed