BDBM26387 Aminopyrimidine amide, 33::N-{4-ethyl-3-[(2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-5-yl)carbamoyl]phenyl}-2,2-difluoro-2H-1,3-benzodioxole-5-carboxamide

SMILES CCc1ccc(NC(=O)c2ccc3OC(F)(F)Oc3c2)cc1C(=O)Nc1cnc(Nc2ccc(cc2)N2CCN(C)CC2)nc1

InChI Key InChIKey=ORWVKNRINMANEF-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 26387   

TargetTyrosine-protein kinase Lck(Human)
Amgen

LigandPNGBDBM26387(N-{4-ethyl-3-[(2-{[4-(4-methylpiperazin-1-yl)pheny...)
Affinity DataIC50: 6nMpH: 7.5 T: 2°CAssay Description:The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2009
Entry Details Article
PubMed
TargetAngiopoietin-1 receptor(Human)
Amgen

LigandPNGBDBM26387(N-{4-ethyl-3-[(2-{[4-(4-methylpiperazin-1-yl)pheny...)
Affinity DataIC50: 2.50E+4nMAssay Description:The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2009
Entry Details Article
PubMed
LigandPNGBDBM26387(N-{4-ethyl-3-[(2-{[4-(4-methylpiperazin-1-yl)pheny...)
Affinity DataIC50: 5.00E+3nMAssay Description:The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2009
Entry Details Article
PubMed
LigandPNGBDBM26387(N-{4-ethyl-3-[(2-{[4-(4-methylpiperazin-1-yl)pheny...)
Affinity DataIC50: 233nMAssay Description:The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2009
Entry Details Article
PubMed
LigandPNGBDBM26387(N-{4-ethyl-3-[(2-{[4-(4-methylpiperazin-1-yl)pheny...)
Affinity DataIC50: 2.50E+4nMAssay Description:The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2009
Entry Details Article
PubMed