BDBM264181 (2R)-2-[(3S)-3,4- dimethylpiperazin-1- yl]-N-(3-{5-fluoro-2- [(3-methoxy-1- methyl-1H-pyrazol-4- yl)amino]pyrimidin- 4-yl}-1H-indol-7- yl)propanamide::US10167276, Example 5::US10654835, Example 5::US11247983, Example 5::US9714236, 5

SMILES COc1nn(C)cc1Nc1ncc(F)c(n1)-c1c[nH]c2c(NC(=O)[C@@H](C)N3CCN(C)[C@@H](C)C3)cccc12

InChI Key InChIKey=HKMXSVZYKLTDAP-UHFFFAOYSA-N

Data  12 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 264181   

TargetTyrosine-protein kinase JAK1 [866-1154](Human)
Astrazeneca

US Patent
LigandPNGBDBM264181((2R)-2-[(3S)-3,4- dimethylpiperazin-1- yl]-N-(3-{5...)
Affinity DataIC50: 24nMpH: 7.3Assay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2018
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK2 [831-1132](Human)
Astrazeneca

US Patent
LigandPNGBDBM264181((2R)-2-[(3S)-3,4- dimethylpiperazin-1- yl]-N-(3-{5...)
Affinity DataIC50: 1.04E+4nMpH: 7.3Assay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2018
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK3 [781-1124](Human)
Astrazeneca

US Patent
LigandPNGBDBM264181((2R)-2-[(3S)-3,4- dimethylpiperazin-1- yl]-N-(3-{5...)
Affinity DataIC50: 3.00E+4nMpH: 7.3Assay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2018
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK1 [866-1154](Human)
Astrazeneca

US Patent
LigandPNGBDBM264181((2R)-2-[(3S)-3,4- dimethylpiperazin-1- yl]-N-(3-{5...)
Affinity DataIC50: 24nMAssay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK2 [808-1132](Human)
Dizal (Jiangsu) Pharmaceutical

US Patent
LigandPNGBDBM264181((2R)-2-[(3S)-3,4- dimethylpiperazin-1- yl]-N-(3-{5...)
Affinity DataIC50: 1.04E+4nMAssay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK3 [811-1124](Human)
Dizal (Jiangsu) Pharmaceutical

US Patent
LigandPNGBDBM264181((2R)-2-[(3S)-3,4- dimethylpiperazin-1- yl]-N-(3-{5...)
Affinity DataIC50: 3.00E+4nMAssay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK1 [866-1154](Human)
Astrazeneca

US Patent
LigandPNGBDBM264181((2R)-2-[(3S)-3,4- dimethylpiperazin-1- yl]-N-(3-{5...)
Affinity DataIC50: 24nMAssay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, PV4774, Carlsbad, Calif.), JAK2 (amino acid...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/1/2021
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK2 [831-1132](Human)
Astrazeneca

US Patent
LigandPNGBDBM264181((2R)-2-[(3S)-3,4- dimethylpiperazin-1- yl]-N-(3-{5...)
Affinity DataIC50: 1.04E+4nMAssay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, PV4774, Carlsbad, Calif.), JAK2 (amino acid...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/1/2021
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK3 [781-1124](Human)
Astrazeneca

US Patent
LigandPNGBDBM264181((2R)-2-[(3S)-3,4- dimethylpiperazin-1- yl]-N-(3-{5...)
Affinity DataIC50: 3.00E+4nMAssay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, PV4774, Carlsbad, Calif.), JAK2 (amino acid...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/1/2021
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK1 [866-1154](Human)
Astrazeneca

US Patent
LigandPNGBDBM264181((2R)-2-[(3S)-3,4- dimethylpiperazin-1- yl]-N-(3-{5...)
Affinity DataIC50: 24nMAssay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2022
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK2 [831-1132](Human)
Astrazeneca

US Patent
LigandPNGBDBM264181((2R)-2-[(3S)-3,4- dimethylpiperazin-1- yl]-N-(3-{5...)
Affinity DataIC50: 1.04E+4nMAssay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2022
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK3 [781-1124](Human)
Astrazeneca

US Patent
LigandPNGBDBM264181((2R)-2-[(3S)-3,4- dimethylpiperazin-1- yl]-N-(3-{5...)
Affinity DataIC50: 3.00E+4nMAssay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2022
Entry Details
Go to US Patent