BDBM267346 4-(5-((5-(3-chloro- 5-cyanophenoxy)- 6-oxo-4- (trifluoromethyl) pyrimidin-1(6H)- yl)methyl)-6-oxo- 1,6- dihydropyridazin-3- yl)-2- fluorobenzonitrile::US10189831, Example 122::US9718819, 122

SMILES Fc1cc(ccc1C#N)-c1cc(Cn2cnc(c(Oc3cc(Cl)cc(c3)C#N)c2=O)C(F)(F)F)c(=O)[nH]n1

InChI Key InChIKey=MYIMVDTWYPRMIZ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 267346   

TargetGag-Pol polyprotein(HIV-1)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM267346(4-(5-((5-(3-chloro- 5-cyanophenoxy)- 6-oxo-4- (tri...)
Affinity DataIC50: 6nMpH: 7.8 T: 2°CAssay Description:The heterodimeric nucleic acid substrate used in the HIV-1 RT polymerase reactions was generated by annealing the DNA primer, biotinylated pD500 (Sig...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2018
Entry Details
Go to US Patent

TargetGag-Pol polyprotein(HIV-1)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM267346(4-(5-((5-(3-chloro- 5-cyanophenoxy)- 6-oxo-4- (tri...)
Affinity DataIC50: 6nMAssay Description:The heterodimeric nucleic acid substrate used in the HIV-1 RT polymerase reactions was generated by annealing the DNA primer, biotinylated pD500 (Sig...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2019
Entry Details
Go to US Patent