BDBM267350 3-chloro-5-((6-oxo- 1-((3-oxo-6-(1H- pyrrolo[2,3- b]pyridin-4-yl)-2,3- dihydropyridazin-4- yl)methyl)-4- (trifluoromethyl)- 1,6- dihydropyrimidin- 5- yl)oxy)benzonitrile::US10189831, Example 126::US9718819, 126

SMILES FC(F)(F)c1ncn(Cc2cc(n[nH]c2=O)-c2ccnc3[nH]ccc23)c(=O)c1Oc1cc(Cl)cc(c1)C#N

InChI Key InChIKey=BSUORRZSPQGGHL-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 267350   

TargetGag-Pol polyprotein(HIV-1)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM267350(3-chloro-5-((6-oxo- 1-((3-oxo-6-(1H- pyrrolo[2,3- ...)
Affinity DataIC50: 4nMpH: 7.8 T: 2°CAssay Description:The heterodimeric nucleic acid substrate used in the HIV-1 RT polymerase reactions was generated by annealing the DNA primer, biotinylated pD500 (Sig...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2018
Entry Details
Go to US Patent

TargetGag-Pol polyprotein(HIV-1)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM267350(3-chloro-5-((6-oxo- 1-((3-oxo-6-(1H- pyrrolo[2,3- ...)
Affinity DataIC50: 4nMAssay Description:The heterodimeric nucleic acid substrate used in the HIV-1 RT polymerase reactions was generated by annealing the DNA primer, biotinylated pD500 (Sig...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2019
Entry Details
Go to US Patent