BDBM267469 US10688100, Compound 45::US10966985, Compound 45::US9718822, 45 Diastereomer 1::US9750744, Example 45 isomer 1::US9902741, Example 45 isomer 2

SMILES O=C3NC[C@H](O)COc1ccc(F)cc1[C@H]2CC(F)(F)CN2c5ccn4ncc3c4n5

InChI Key InChIKey=RQZIXOOARXBNHW-UHFFFAOYSA-N

Data  10 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 267469   

TargetProto-oncogene tyrosine-protein kinase ROS [L2026M](Human)
Array Biopharma

US Patent
LigandChemical structure of BindingDB Monomer ID 267469BDBM267469(US9718822, 45 Diastereomer 1 | US9750744, Example ...)
Affinity DataIC50: 4.60nMAssay Description:The potency of a compound inhibiting wild type and exemplary mutant ROS1 kinases was determined using CisBio's HTRF Kinease-TK assay technology. ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2021
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase ROS [D2033N](Human)
Array Biopharma

US Patent
LigandChemical structure of BindingDB Monomer ID 267469BDBM267469(US9718822, 45 Diastereomer 1 | US9750744, Example ...)
Affinity DataIC50: 4.60nMAssay Description:The potency of a compound inhibiting wild type and exemplary mutant ROS1 kinases was determined using CisBio's HTRF Kinease-TK assay technology. ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase ROS(Human)
Array Biopharma

US Patent
LigandChemical structure of BindingDB Monomer ID 267469BDBM267469(US9718822, 45 Diastereomer 1 | US9750744, Example ...)
Affinity DataIC50: 6.10nMAssay Description:The potency of a compound inhibiting wild type and exemplary mutant ROS1 kinases was determined using CisBio's HTRF Kinease-TK assay technology. ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2021
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase ROS(Human)
Array Biopharma

US Patent
LigandChemical structure of BindingDB Monomer ID 267469BDBM267469(US9718822, 45 Diastereomer 1 | US9750744, Example ...)
Affinity DataIC50: 6.10nMAssay Description:The potency of a compound inhibiting wild type and exemplary mutant ROS1 kinases was determined using CisBio's HTRF Kinease-TK assay technology. ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase ROS [D2033N](Human)
Array Biopharma

US Patent
LigandChemical structure of BindingDB Monomer ID 267469BDBM267469(US9718822, 45 Diastereomer 1 | US9750744, Example ...)
Affinity DataIC50: 16.8nMAssay Description:The potency of a compound inhibiting wild type and exemplary mutant ROS1 kinases was determined using CisBio's HTRF Kinease-TK assay technology. ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2021
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase ROS [G2032R](Human)
Array Biopharma

US Patent
LigandChemical structure of BindingDB Monomer ID 267469BDBM267469(US9718822, 45 Diastereomer 1 | US9750744, Example ...)
Affinity DataIC50: 16.8nMAssay Description:The potency of a compound inhibiting wild type and exemplary mutant ROS1 kinases was determined using CisBio's HTRF Kinease-TK assay technology. ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Array Biopharma

US Patent
LigandChemical structure of BindingDB Monomer ID 267469BDBM267469(US9718822, 45 Diastereomer 1 | US9750744, Example ...)
Affinity DataIC50: 55nMpH: 7.5Assay Description:The ability of a compound to bind to TrkA was measured by Invitrogen's LanthaScreen Eu Kinase Binding Assay. In this assay, His-tagged recombinan...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2018
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Array Biopharma

US Patent
LigandChemical structure of BindingDB Monomer ID 267469BDBM267469(US9718822, 45 Diastereomer 1 | US9750744, Example ...)
Affinity DataIC50: 55nMAssay Description:The ability of a compound to bind to TrkA was measured by Invitrogen's LanthaScreen Eu Kinase Binding Assay. In this assay, His-tagged recombinan...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2019
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase ROS [G2032R](Human)
Array Biopharma

US Patent
LigandChemical structure of BindingDB Monomer ID 267469BDBM267469(US9718822, 45 Diastereomer 1 | US9750744, Example ...)
Affinity DataIC50: 114nMAssay Description:The potency of a compound inhibiting wild type and exemplary mutant ROS1 kinases was determined using CisBio's HTRF Kinease-TK assay technology. ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2021
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase ROS [L2026M](Human)
Array Biopharma

US Patent
LigandChemical structure of BindingDB Monomer ID 267469BDBM267469(US9718822, 45 Diastereomer 1 | US9750744, Example ...)
Affinity DataIC50: 114nMAssay Description:The potency of a compound inhibiting wild type and exemplary mutant ROS1 kinases was determined using CisBio's HTRF Kinease-TK assay technology. ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details
US Patent