BDBM26793 benzimidazole analog., 19::tert-butyl (3S,4S)-3-(hydroxycarbamoyl)-4-[(4-{[2-(propan-2-yl)-1H-1,3-benzodiazol-1-yl]methyl}benzene)amido]pyrrolidine-1-carboxylate

SMILES CC(C)c1nc2ccccc2n1Cc1ccc(cc1)C(=O)N[C@@H]1CN(C[C@@H]1C(=O)NO)C(=O)OC(C)(C)C

InChI Key InChIKey=HWRTYSUSQVJAGF-UHFFFAOYSA-N

Data  4 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 26793   

LigandPNGBDBM26793(tert-butyl (3S,4S)-3-(hydroxycarbamoyl)-4-[(4-{[2-...)
Affinity DataIC50: 1nMpH: 7.5 T: 2°CAssay Description:The compounds were tested for enzyme inhibition using fluorescence resonance energy transfer (FRET) assay. Fluorescence measurements were performed i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2009
Entry Details Article
PubMed
TargetMacrophage metalloelastase(Human)
Bristol-Myers Squibb

LigandPNGBDBM26793(tert-butyl (3S,4S)-3-(hydroxycarbamoyl)-4-[(4-{[2-...)
Affinity DataIC50: 390nMpH: 7.5 T: 2°CAssay Description:The compounds were tested for enzyme inhibition using fluorescence resonance energy transfer (FRET) assay. Fluorescence measurements were performed i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2009
Entry Details Article
PubMed
TargetStromelysin-2(Human)
Bristol-Myers Squibb

LigandPNGBDBM26793(tert-butyl (3S,4S)-3-(hydroxycarbamoyl)-4-[(4-{[2-...)
Affinity DataIC50: 4.60E+3nMAssay Description:The compounds were tested for enzyme inhibition using fluorescence resonance energy transfer (FRET) assay. Fluorescence measurements were performed i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2009
Entry Details Article
PubMed
TargetNeutrophil collagenase(Human)
Bristol-Myers Squibb

LigandPNGBDBM26793(tert-butyl (3S,4S)-3-(hydroxycarbamoyl)-4-[(4-{[2-...)
Affinity DataKi: >3.06E+3nMAssay Description:The compounds were tested for enzyme inhibition using fluorescence resonance energy transfer (FRET) assay. Fluorescence measurements were performed i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2009
Entry Details Article
PubMed
TargetMatrilysin(Human)
Bristol-Myers Squibb

LigandPNGBDBM26793(tert-butyl (3S,4S)-3-(hydroxycarbamoyl)-4-[(4-{[2-...)
Affinity DataKi:  3.50E+3nM ΔG°:  -7.44kcal/molepH: 7.5 T: 2°CAssay Description:The compounds were tested for enzyme inhibition using fluorescence resonance energy transfer (FRET) assay. Fluorescence measurements were performed i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2009
Entry Details Article
PubMed
TargetStromelysin-1(Human)
Bristol-Myers Squibb

LigandPNGBDBM26793(tert-butyl (3S,4S)-3-(hydroxycarbamoyl)-4-[(4-{[2-...)
Affinity DataKi:  3.92E+3nM ΔG°:  -7.37kcal/molepH: 7.5 T: 2°CAssay Description:The compounds were tested for enzyme inhibition using fluorescence resonance energy transfer (FRET) assay. Fluorescence measurements were performed i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2009
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Bristol-Myers Squibb

LigandPNGBDBM26793(tert-butyl (3S,4S)-3-(hydroxycarbamoyl)-4-[(4-{[2-...)
Affinity DataKi: >5.03E+3nMAssay Description:The compounds were tested for enzyme inhibition using fluorescence resonance energy transfer (FRET) assay. Fluorescence measurements were performed i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2009
Entry Details Article
PubMed