BDBM268027 2-[(3R,5R)-3,5-dimethylmorpholin-4-yl]-4-isopropoxy-8-(1H-pyrazol-5-yl)-1,7-naphthyridine::US10772893, Example 59::US11529356, Example 59::US9549932, 59

SMILES CC(C)Oc1cc(nc2c(nccc12)-c1ccn[nH]1)N1[C@H](C)COC[C@H]1C

InChI Key InChIKey=XXIDXEBDJANSDE-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 268027   

TargetSerine/threonine-protein kinase ATR(Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM268027(2-[(3R,5R)-3,5-dimethylmorpholin-4-yl]-4-isopropox...)
Affinity DataIC50: 730nMpH: 7.0Assay Description:To determine of binding activity of the test compounds, full-length human ATR protein was expressed and purified together with ATRIP as described abo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2018
Entry Details
US Patent

TargetATR-interacting protein/Serine/threonine-protein kinase ATR(Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM268027(2-[(3R,5R)-3,5-dimethylmorpholin-4-yl]-4-isopropox...)
Affinity DataIC50: 730nMAssay Description:To determine of binding activity of the test compounds, full-length human ATR protein was expressed and purified together with ATRIP as described abo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/25/2021
Entry Details
US Patent

TargetATR-interacting protein/Serine/threonine-protein kinase ATR(Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM268027(2-[(3R,5R)-3,5-dimethylmorpholin-4-yl]-4-isopropox...)
Affinity DataIC50: 730nMAssay Description:For the assay 50 nl of a 100-fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2023
Entry Details
US Patent

TargetSerine/threonine-protein kinase ATR(Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM268027(2-[(3R,5R)-3,5-dimethylmorpholin-4-yl]-4-isopropox...)
Affinity DataIC50: 730nMAssay Description:Inhibition of 5'-TAMRA-labeled tracer 3',6'-bis(dimethylamino)-N-(4-{[2(1H-indol-4-yl)-6-(morpholin-4-yl)-pyrimidin-4-yl]amino}butyl)-3-oxo-3H-spiro[...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetATR-interacting protein/Serine/threonine-protein kinase ATR(Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM268027(2-[(3R,5R)-3,5-dimethylmorpholin-4-yl]-4-isopropox...)
Affinity DataIC50: 1.25E+3nMAssay Description:To determine of binding activity of the test compounds, full-length human ATR protein was expressed and purified together with ATRIP as described abo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/25/2021
Entry Details
US Patent

TargetSerine/threonine-protein kinase ATR(Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM268027(2-[(3R,5R)-3,5-dimethylmorpholin-4-yl]-4-isopropox...)
Affinity DataIC50: 1.25E+3nMpH: 7.0Assay Description:To determine of binding activity of the test compounds, full-length human ATR protein was expressed and purified together with ATRIP as described abo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2018
Entry Details
US Patent

TargetATR-interacting protein/Serine/threonine-protein kinase ATR(Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM268027(2-[(3R,5R)-3,5-dimethylmorpholin-4-yl]-4-isopropox...)
Affinity DataIC50: 1.25E+3nMAssay Description:For the assay 50 nl of a 100-fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2023
Entry Details
US Patent