BDBM274319 6-(4-chlorophenyl)-3-cyclopropyl-5-(3,8-di methyl-[1,2,4]triazolo[4,3-a]pyridin-6-yl)-2-(2-methoxypyridin-3-yl)-1-methyl-5,6-dihydropyrrolo[3,4-b]pyrrol-4(1H)-one::US9550796, Example 120

SMILES COc1ncccc1-c1c(C2CC2)c2C(=O)N(C(c2n1C)c1ccc(Cl)cc1)c1cc(C)c2nnc(C)n2c1

InChI Key InChIKey=VQOLKEMPAJVXHY-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 274319   

TargetBromodomain-containing protein 4 [44-477](Human)
Novartis

US Patent
LigandPNGBDBM274319(6-(4-chlorophenyl)-3-cyclopropyl-5-(3,8-di methyl-...)
Affinity DataIC50: 11nMpH: 7.5Assay Description:All assays were performed in 384-well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2018
Entry Details
Go to US Patent

TargetBromodomain-containing protein 3(Human)
Novartis

US Patent
LigandPNGBDBM274319(6-(4-chlorophenyl)-3-cyclopropyl-5-(3,8-di methyl-...)
Affinity DataIC50: 11nMpH: 7.5Assay Description:All assays were performed in 384-well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2018
Entry Details
Go to US Patent

TargetCREB-binding protein(Human)
Novartis

US Patent
LigandPNGBDBM274319(6-(4-chlorophenyl)-3-cyclopropyl-5-(3,8-di methyl-...)
Affinity DataIC50: 1.60E+3nMpH: 7.5 T: 2°CAssay Description:All assays were performed in 384-well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2018
Entry Details
Go to US Patent

TargetBromodomain-containing protein 4(Human)
University of Texas Medical Branch

Curated by ChEMBL
LigandPNGBDBM274319(6-(4-chlorophenyl)-3-cyclopropyl-5-(3,8-di methyl-...)
Affinity DataIC50: 11nMAssay Description:Inhibition of His-tagged BRD4 (44 to 477 residues) (unknown origin) using acetyl-histone H4 as substrate after 35 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/10/2020
Entry Details Article
PubMed