BDBM276744 US10071991, Compound (I-M2-2S,4R)::US10800764, Compound (I-M7-2R,4S)::US11214566, Compound (I-M2-2S,4R)

SMILES CC1(C)CCC(=CC1)c1nc(ccc1NC(=O)c1nc(c[nH]1)C#N)[C@@H]1CC(C)(C)O[C@@](C)(C1)C(O)=O

InChI Key InChIKey=MZZYKYGSHDFBTD-UHFFFAOYSA-N

Data  14 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 276744   

TargetMacrophage colony-stimulating factor 1 receptor(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM276744(US10071991, Compound (I-M2-2S,4R) | US10800764, Co...)
Affinity DataIC50: 2.20nMpH: 7.0 T: 2°CAssay Description:In this assay, recombinant human, dog or rat c-fms catalyzed the phosphorylation of the FMS peptide substrate, SYEGNSYTFIDPTQ, with the phosphorylate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
Go to US Patent

TargetColony stimulating factor 1 receptor(Dog)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM276744(US10071991, Compound (I-M2-2S,4R) | US10800764, Co...)
Affinity DataIC50: 2nMpH: 7.0 T: 2°CAssay Description:In this assay, recombinant human, dog or rat c-fms catalyzed the phosphorylation of the FMS peptide substrate, SYEGNSYTFIDPTQ, with the phosphorylate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
Go to US Patent

TargetMacrophage colony-stimulating factor 1 receptor(Rat)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM276744(US10071991, Compound (I-M2-2S,4R) | US10800764, Co...)
Affinity DataIC50: 2.20nMpH: 7.0 T: 2°CAssay Description:In this assay, recombinant human, dog or rat c-fms catalyzed the phosphorylation of the FMS peptide substrate, SYEGNSYTFIDPTQ, with the phosphorylate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
Go to US Patent

TargetMacrophage colony-stimulating factor 1 receptor(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM276744(US10071991, Compound (I-M2-2S,4R) | US10800764, Co...)
Affinity DataIC50: 2.93E+3nMAssay Description:Representative compounds of the present invention were additionally tested in an in vitro assay measuring inhibition of CSF-1 induced monocyte MCP-1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2021
Entry Details
Go to US Patent

TargetMacrophage colony-stimulating factor 1 receptor(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM276744(US10071991, Compound (I-M2-2S,4R) | US10800764, Co...)
Affinity DataIC50: 2.37E+3nMAssay Description:Representative compounds of the present invention were additionally tested in an in vitro assay measuring inhibition of CSF-1 induced monocyte MCP-1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2021
Entry Details
Go to US Patent

TargetMacrophage colony-stimulating factor 1 receptor(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM276744(US10071991, Compound (I-M2-2S,4R) | US10800764, Co...)
Affinity DataIC50: 2.20nMAssay Description:Materials:Human c-fms protein (N-terminal 6His-tagged, amino acids 538-972), dog c-fms protein (N-terminal 6His-tagged, amino acids 535-967) and rat ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2021
Entry Details
Go to US Patent

TargetReceptor protein-tyrosine kinase(Dog)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM276744(US10071991, Compound (I-M2-2S,4R) | US10800764, Co...)
Affinity DataIC50: 2nMAssay Description:Materials:Human c-fms protein (N-terminal 6His-tagged, amino acids 538-972), dog c-fms protein (N-terminal 6His-tagged, amino acids 535-967) and rat ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2021
Entry Details
Go to US Patent

TargetMacrophage colony-stimulating factor 1 receptor(Rat)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM276744(US10071991, Compound (I-M2-2S,4R) | US10800764, Co...)
Affinity DataIC50: 2.20nMAssay Description:Materials:Human c-fms protein (N-terminal 6His-tagged, amino acids 538-972), dog c-fms protein (N-terminal 6His-tagged, amino acids 535-967) and rat ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2021
Entry Details
Go to US Patent

TargetMacrophage colony-stimulating factor 1 receptor(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM276744(US10071991, Compound (I-M2-2S,4R) | US10800764, Co...)
Affinity DataIC50: 7.10nMAssay Description:Materials:Human c-fms protein (N-terminal 6His-tagged, amino acids 538-972), dog c-fms protein (N-terminal 6His-tagged, amino acids 535-967) and rat ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2021
Entry Details
Go to US Patent

TargetReceptor protein-tyrosine kinase(Dog)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM276744(US10071991, Compound (I-M2-2S,4R) | US10800764, Co...)
Affinity DataIC50: 8nMAssay Description:Materials:Human c-fms protein (N-terminal 6His-tagged, amino acids 538-972), dog c-fms protein (N-terminal 6His-tagged, amino acids 535-967) and rat ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2021
Entry Details
Go to US Patent

TargetMacrophage colony-stimulating factor 1 receptor(Rat)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM276744(US10071991, Compound (I-M2-2S,4R) | US10800764, Co...)
Affinity DataIC50: 9.60nMAssay Description:Materials:Human c-fms protein (N-terminal 6His-tagged, amino acids 538-972), dog c-fms protein (N-terminal 6His-tagged, amino acids 535-967) and rat ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2021
Entry Details
Go to US Patent

TargetMacrophage colony-stimulating factor 1 receptor(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM276744(US10071991, Compound (I-M2-2S,4R) | US10800764, Co...)
Affinity DataIC50: 2.20nMAssay Description:In this assay, recombinant human, dog or rat c-fms catalyzed the phosphorylation of the FMS peptide substrate, SYEGNSYTFIDPTQ, with the phosphorylate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2022
Entry Details
Go to US Patent

TargetReceptor protein-tyrosine kinase(Dog)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM276744(US10071991, Compound (I-M2-2S,4R) | US10800764, Co...)
Affinity DataIC50: 2nMAssay Description:In this assay, recombinant human, dog or rat c-fms catalyzed the phosphorylation of the FMS peptide substrate, SYEGNSYTFIDPTQ, with the phosphorylate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2022
Entry Details
Go to US Patent

TargetMacrophage colony-stimulating factor 1 receptor(Rat)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM276744(US10071991, Compound (I-M2-2S,4R) | US10800764, Co...)
Affinity DataIC50: 2.20nMAssay Description:In this assay, recombinant human, dog or rat c-fms catalyzed the phosphorylation of the FMS peptide substrate, SYEGNSYTFIDPTQ, with the phosphorylate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2022
Entry Details
Go to US Patent