BDBM277147 (S) or (R)-4-(3- methylpiperidin-1-yl)-7- ((2- (trifluoromethyl)pyridin-4- yl)methyl)-5,6,7,8- tetrahydro-1,7- naphthyridine-2- carboxamide::US10072003, Example 5-5A::US10072003, Example 5-5B

SMILES CC1CCCN(C1)c1cc(nc2CN(Cc3ccnc(c3)C(F)(F)F)CCc12)C(N)=O

InChI Key InChIKey=BXFWJNUYWOSVQS-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 277147   

TargetMetabotropic glutamate receptor 2(Human)
TBA

US Patent
LigandPNGBDBM277147(US10072003, Example 5-5B | (S) or (R)-4-(3- methyl...)
Affinity DataIC50: 1.29E+4nMAssay Description:The utility of the compounds of the invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR2 activity, may be demon...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
US Patent

TargetMetabotropic glutamate receptor 2(Human)
TBA

US Patent
LigandPNGBDBM277147(US10072003, Example 5-5B | (S) or (R)-4-(3- methyl...)
Affinity DataIC50: 1.84E+4nMAssay Description:The utility of the compounds of the invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR2 activity, may be demon...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
US Patent