BDBM278863 2-{[(1R,2S)-2- aminocyclohexyl]amino}- N-(1-methyl-5- (trifluoromethyl)-1H- pyrazol-4- yl]thieno[2,3-b] pyrazine-7- carboxamide trifluoroacetate::US10040802, Example 42

SMILES Cn4ncc(NC(=O)c2csc3ncc(N[C@@H]1CCCC[C@@H]1N)nc23)c4C(F)(F)F

InChI Key InChIKey=KBZHVTIEHSKHFD-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 278863   

TargetInterleukin-1 receptor-associated kinase 4(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM278863(2-{[(1R,2S)-2- aminocyclohexyl]amino}- N-(1-methyl...)
Affinity DataIC50: 16nMpH: 7.2Assay Description:The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2018
Entry Details
US Patent