BDBM278880 2-[(1S,4S)- or (1R,4R)- 2,5-diazabicyclo [2.2.2]oct-2-yl]-N- [4-(difluoromethyl) thiophen-3-yl] thieno[2,3-b] pyrazine-7- carboxamide trifluoroacetate::US10040802, Example 59

SMILES FC(F)c1cscc1NC(=O)c1csc2ncc(nc12)N1C[C@H]2CC[C@@H]1CN2

InChI Key InChIKey=RPTKRJZAUQKBQJ-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 278880   

TargetInterleukin-1 receptor-associated kinase 4(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM278880(2-[(1S,4S)- or (1R,4R)- 2,5-diazabicyclo [2.2.2]oc...)
Affinity DataIC50: 21nMpH: 7.2Assay Description:The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2018
Entry Details
US Patent