BDBM278983 5-(2-ethoxy-3-pyridyl)-N-[(1-methylpyrazol-4-yl)methyl]-1-propyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 13::US10512632, Example 13::US10618913, Example S13::US10766893, Example S13::US10806718, Example 13::US11026923, Example 13::US11491140, Example 13::US11634416, Example 13

SMILES CCCn1ncc2nc(cc(NCc3cnn(C)c3)c12)-c1cccnc1OCC

InChI Key InChIKey=VBBYLKGVLRZVDT-UHFFFAOYSA-N

Data  24 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 24 hits for monomerid = 278983   

LigandPNGBDBM278983(5-(2-ethoxy-3-pyridyl)-N-[(1-methylpyrazol-4-yl)me...)
Affinity DataIC50: 90nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2021
Entry Details
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LigandPNGBDBM278983(5-(2-ethoxy-3-pyridyl)-N-[(1-methylpyrazol-4-yl)me...)
Affinity DataIC50: 340nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2023
Entry Details
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LigandPNGBDBM278983(5-(2-ethoxy-3-pyridyl)-N-[(1-methylpyrazol-4-yl)me...)
Affinity DataIC50: 15nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2023
Entry Details
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LigandPNGBDBM278983(5-(2-ethoxy-3-pyridyl)-N-[(1-methylpyrazol-4-yl)me...)
Affinity DataIC50: 90nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2023
Entry Details
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LigandPNGBDBM278983(5-(2-ethoxy-3-pyridyl)-N-[(1-methylpyrazol-4-yl)me...)
Affinity DataIC50: 340nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/20/2023
Entry Details
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LigandPNGBDBM278983(5-(2-ethoxy-3-pyridyl)-N-[(1-methylpyrazol-4-yl)me...)
Affinity DataIC50: 15nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/20/2023
Entry Details
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LigandPNGBDBM278983(5-(2-ethoxy-3-pyridyl)-N-[(1-methylpyrazol-4-yl)me...)
Affinity DataIC50: 90nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/20/2023
Entry Details
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LigandPNGBDBM278983(5-(2-ethoxy-3-pyridyl)-N-[(1-methylpyrazol-4-yl)me...)
Affinity DataIC50: 340nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 uL samples containing a fixed amount of the PDE1 enzyme (suff...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2021
Entry Details
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LigandPNGBDBM278983(5-(2-ethoxy-3-pyridyl)-N-[(1-methylpyrazol-4-yl)me...)
Affinity DataIC50: 15nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 uL samples containing a fixed amount of the PDE1 enzyme (suff...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2021
Entry Details
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LigandPNGBDBM278983(5-(2-ethoxy-3-pyridyl)-N-[(1-methylpyrazol-4-yl)me...)
Affinity DataIC50: 90nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 uL samples containing a fixed amount of the PDE1 enzyme (suff...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2021
Entry Details
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LigandPNGBDBM278983(5-(2-ethoxy-3-pyridyl)-N-[(1-methylpyrazol-4-yl)me...)
Affinity DataIC50: 340nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2021
Entry Details
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LigandPNGBDBM278983(5-(2-ethoxy-3-pyridyl)-N-[(1-methylpyrazol-4-yl)me...)
Affinity DataIC50: 15nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2021
Entry Details
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LigandPNGBDBM278983(5-(2-ethoxy-3-pyridyl)-N-[(1-methylpyrazol-4-yl)me...)
Affinity DataIC50: 90nMpH: 7.6 T: 2°CAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2018
Entry Details
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LigandPNGBDBM278983(5-(2-ethoxy-3-pyridyl)-N-[(1-methylpyrazol-4-yl)me...)
Affinity DataIC50: 340nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/26/2021
Entry Details
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LigandPNGBDBM278983(5-(2-ethoxy-3-pyridyl)-N-[(1-methylpyrazol-4-yl)me...)
Affinity DataIC50: 15nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/26/2021
Entry Details
Go to US Patent

LigandPNGBDBM278983(5-(2-ethoxy-3-pyridyl)-N-[(1-methylpyrazol-4-yl)me...)
Affinity DataIC50: 90nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/26/2021
Entry Details
Go to US Patent

LigandPNGBDBM278983(5-(2-ethoxy-3-pyridyl)-N-[(1-methylpyrazol-4-yl)me...)
Affinity DataIC50: 340nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2020
Entry Details
Go to US Patent

LigandPNGBDBM278983(5-(2-ethoxy-3-pyridyl)-N-[(1-methylpyrazol-4-yl)me...)
Affinity DataIC50: 15nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2020
Entry Details
Go to US Patent

LigandPNGBDBM278983(5-(2-ethoxy-3-pyridyl)-N-[(1-methylpyrazol-4-yl)me...)
Affinity DataIC50: 90nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2020
Entry Details
Go to US Patent

LigandPNGBDBM278983(5-(2-ethoxy-3-pyridyl)-N-[(1-methylpyrazol-4-yl)me...)
Affinity DataIC50: 340nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/18/2020
Entry Details
Go to US Patent

LigandPNGBDBM278983(5-(2-ethoxy-3-pyridyl)-N-[(1-methylpyrazol-4-yl)me...)
Affinity DataIC50: 15nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/18/2020
Entry Details
Go to US Patent

LigandPNGBDBM278983(5-(2-ethoxy-3-pyridyl)-N-[(1-methylpyrazol-4-yl)me...)
Affinity DataIC50: 90nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/18/2020
Entry Details
Go to US Patent

LigandPNGBDBM278983(5-(2-ethoxy-3-pyridyl)-N-[(1-methylpyrazol-4-yl)me...)
Affinity DataIC50: 340nMpH: 7.6 T: 2°CAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2018
Entry Details
Go to US Patent

LigandPNGBDBM278983(5-(2-ethoxy-3-pyridyl)-N-[(1-methylpyrazol-4-yl)me...)
Affinity DataIC50: 15nMpH: 7.6 T: 2°CAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2018
Entry Details
Go to US Patent