BDBM28033 2-aminopyridine analogue, 12::N-{4-[(2-amino-3-chloropyridin-4-yl)oxy]-3-fluorophenyl}-1-(4-fluorophenyl)-4-(2-hydroxyethoxy)-2-oxo-1,2-dihydropyridine-3-carboxamide

SMILES Nc1nccc(Oc2ccc(NC(=O)c3c(OCCO)ccn(-c4ccc(F)cc4)c3=O)cc2F)c1Cl

InChI Key InChIKey=OWZVZGPZNVFUJF-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 28033   

TargetHepatocyte growth factor receptor(Human)
Bristol-Myers Squibb

LigandPNGBDBM28033(N-{4-[(2-amino-3-chloropyridin-4-yl)oxy]-3-fluorop...)
Affinity DataIC50: 2.60nMpH: 7.5 T: 2°CAssay Description:Kinase activity was assayed using baculovirus expressed GST-Met, and poly(Glu/Tyr) as the substrate in the presence of test compound. Dose response c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/5/2009
Entry Details Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Bristol-Myers Squibb

LigandPNGBDBM28033(N-{4-[(2-amino-3-chloropyridin-4-yl)oxy]-3-fluorop...)
Affinity DataIC50: 2.60nMAssay Description:Inhibition of human c-METMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed