BDBM280336 4-[[5-bromo-2-(5-chloro-2-fluoro-phenyl)-4-pyridyl]amino]-N-(2-hydroxypropyl) pyridine-3-carboxamide::US10030004, Compound 1a::US10501436, Compound 1a::US11053216, Compound 1a

SMILES C[C@H](O)CNC(=O)c1cnccc1Nc1cc(ncc1Br)-c1cc(Cl)ccc1F

InChI Key InChIKey=OUBQQWXHNONJNU-UHFFFAOYSA-N

Data  18 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 18 hits for monomerid = 280336   

TargetActivin receptor type-1B(Human)
Medivation Technologies

US Patent

LigandBDBM280336(4-[[5-bromo-2-(5-chloro-2-fluoro-phenyl)-4-pyridyl...)Copy SMILESCopy InChI

Affinity DataIC50: 9.32E+4nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
10/12/2020
Entry Details
Copy Entry DOIGo to US Patent

Copy Rxn URL

TargetBone morphogenetic protein 10(Human)
Medivation Technologies

US Patent

LigandBDBM280336(4-[[5-bromo-2-(5-chloro-2-fluoro-phenyl)-4-pyridyl...)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+5nMMore data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
2/6/2022
Entry Details
Copy Entry DOIGo to US Patent

Copy Rxn URL

TargetTGF-beta receptor type-1(Human)
Medivation Technologies

US Patent

LigandBDBM280336(4-[[5-bromo-2-(5-chloro-2-fluoro-phenyl)-4-pyridyl...)Copy SMILESCopy InChI

Affinity DataIC50: 250nMMore data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
2/6/2022
Entry Details
Copy Entry DOIGo to US Patent

Copy Rxn URL

TargetActivin receptor type-1B(Human)
Medivation Technologies

US Patent

LigandBDBM280336(4-[[5-bromo-2-(5-chloro-2-fluoro-phenyl)-4-pyridyl...)Copy SMILESCopy InChI

Affinity DataIC50: 9.32E+4nMMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
2/6/2022
Entry Details
Copy Entry DOIGo to US Patent

Copy Rxn URL

TargetBone morphogenetic protein receptor type-1A(Human)
Medivation Technologies

US Patent

LigandBDBM280336(4-[[5-bromo-2-(5-chloro-2-fluoro-phenyl)-4-pyridyl...)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+5nMMore data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
2/6/2022
Entry Details
Copy Entry DOIGo to US Patent

Copy Rxn URL

TargetActivin receptor type-1(Human)
Medivation Technologies

US Patent

LigandBDBM280336(4-[[5-bromo-2-(5-chloro-2-fluoro-phenyl)-4-pyridyl...)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+5nMMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
2/6/2022
Entry Details
Copy Entry DOIGo to US Patent

Copy Rxn URL

TargetSerine/threonine-protein kinase receptor R3(Human)
Medivation Technologies

US Patent

LigandBDBM280336(4-[[5-bromo-2-(5-chloro-2-fluoro-phenyl)-4-pyridyl...)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+5nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
2/6/2022
Entry Details
Copy Entry DOIGo to US Patent

Copy Rxn URL

TargetBone morphogenetic protein receptor type-1B(Human)
Medivation Technologies

US Patent

LigandBDBM280336(4-[[5-bromo-2-(5-chloro-2-fluoro-phenyl)-4-pyridyl...)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+5nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
10/12/2020
Entry Details
Copy Entry DOIGo to US Patent

Copy Rxn URL

TargetTGF-beta receptor type-1(Human)
Medivation Technologies

US Patent

LigandBDBM280336(4-[[5-bromo-2-(5-chloro-2-fluoro-phenyl)-4-pyridyl...)Copy SMILESCopy InChI

Affinity DataIC50: 250nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
10/12/2020
Entry Details
Copy Entry DOIGo to US Patent

Copy Rxn URL

TargetSerine/threonine-protein kinase receptor R3(Human)
Medivation Technologies

US Patent

LigandBDBM280336(4-[[5-bromo-2-(5-chloro-2-fluoro-phenyl)-4-pyridyl...)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+5nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
12/30/2018
Entry Details
Copy Entry DOIGo to US Patent

Copy Rxn URL

TargetBone morphogenetic protein receptor type-1A(Human)
Medivation Technologies

US Patent

LigandBDBM280336(4-[[5-bromo-2-(5-chloro-2-fluoro-phenyl)-4-pyridyl...)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+5nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
10/12/2020
Entry Details
Copy Entry DOIGo to US Patent

Copy Rxn URL

TargetActivin receptor type-1(Human)
Medivation Technologies

US Patent

LigandBDBM280336(4-[[5-bromo-2-(5-chloro-2-fluoro-phenyl)-4-pyridyl...)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+5nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
10/12/2020
Entry Details
Copy Entry DOIGo to US Patent

Copy Rxn URL

TargetSerine/threonine-protein kinase receptor R3(Human)
Medivation Technologies

US Patent

LigandBDBM280336(4-[[5-bromo-2-(5-chloro-2-fluoro-phenyl)-4-pyridyl...)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+5nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
10/12/2020
Entry Details
Copy Entry DOIGo to US Patent

Copy Rxn URL

TargetBone morphogenetic protein receptor type-1B(Mouse)
Medivation Technologies

US Patent

LigandBDBM280336(4-[[5-bromo-2-(5-chloro-2-fluoro-phenyl)-4-pyridyl...)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+5nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
12/30/2018
Entry Details
Copy Entry DOIGo to US Patent

Copy Rxn URL

TargetTGF-beta receptor type-1(Human)
Medivation Technologies

US Patent

LigandBDBM280336(4-[[5-bromo-2-(5-chloro-2-fluoro-phenyl)-4-pyridyl...)Copy SMILESCopy InChI

Affinity DataIC50: 250nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
12/30/2018
Entry Details
Copy Entry DOIGo to US Patent

Copy Rxn URL

TargetActivin receptor type-1B(Human)
Medivation Technologies

US Patent

LigandBDBM280336(4-[[5-bromo-2-(5-chloro-2-fluoro-phenyl)-4-pyridyl...)Copy SMILESCopy InChI

Affinity DataIC50: 9.32E+4nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
12/30/2018
Entry Details
Copy Entry DOIGo to US Patent

Copy Rxn URL

TargetBone morphogenetic protein receptor type-1A(Human)
Medivation Technologies

US Patent

LigandBDBM280336(4-[[5-bromo-2-(5-chloro-2-fluoro-phenyl)-4-pyridyl...)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+5nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
12/30/2018
Entry Details
Copy Entry DOIGo to US Patent

Copy Rxn URL

TargetActivin receptor type-1(Human)
Medivation Technologies

US Patent

LigandBDBM280336(4-[[5-bromo-2-(5-chloro-2-fluoro-phenyl)-4-pyridyl...)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+5nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
12/30/2018
Entry Details
Copy Entry DOIGo to US Patent

Copy Rxn URL