BDBM281058 US10022352, Compound 319

SMILES COc1ccc(cc1)C1(CC1(C)C)C(=O)Nc1ccc2n(C[C@@H](O)CO)c(cc2c1)C(C)(C)C

InChI Key InChIKey=PHOBEWKRVYAPEY-UHFFFAOYSA-N

Data  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 281058   

TargetCystic fibrosis transmembrane conductance regulator(Human)
Vertex Pharmaceuticals

US Patent
LigandPNGBDBM281058(US10022352, Compound 319)
Affinity DataEC50:  39.1nMAssay Description:Single-Channel Recordings activity of wt-CFTR and temperature-corrected ΔF508-CFTR expressed in NIH3T3 cells was observed using excised inside-o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2018
Entry Details
US Patent