BDBM281061 (S)-(3-Isopropyl-1H-pyrazol-5-yl)(3-(6-methyl-4-(1-methyl-1H-pyrazol-4-yl)pyridin-2-yl)pyrrolidin-1-yl)methanone::US10022354, Example 1

SMILES CC(C)c1cc([nH]n1)C(=O)N1CC[C@@H](C1)c1cc(cc(C)n1)-c1cnn(C)c1

InChI Key InChIKey=LNMSTPSCCSYARO-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 281061   

TargetLysine-specific demethylase 5A(Human)
Genentech

US Patent
LigandPNGBDBM281061((S)-(3-Isopropyl-1H-pyrazol-5-yl)(3-(6-methyl-4-(1...)
Affinity DataIC50: 0.170nMpH: 7.0 T: 2°CAssay Description:Full length KDM5A enzyme was expressed and purified inhouse. Biotin-H3K4me3 peptide was purchased from New England Biolabs. HTRF reagents (containing...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2018
Entry Details
Go to US Patent

TargetLysine-specific demethylase 5A(Human)
Genentech

US Patent
LigandPNGBDBM281061((S)-(3-Isopropyl-1H-pyrazol-5-yl)(3-(6-methyl-4-(1...)
Affinity DataIC50: 770nMAssay Description:Inhibition of KDM5A (unknown origin ) by Alphascreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetLysine-specific demethylase 5A(Human)
Genentech

US Patent
LigandPNGBDBM281061((S)-(3-Isopropyl-1H-pyrazol-5-yl)(3-(6-methyl-4-(1...)
Affinity DataIC50: 770nMAssay Description:Inhibition of KDM5A (unknown origin ) demethylase activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed