BDBM282451 2-(4-(4-amino-7-methyl-7H- pyrrolo[2,3-d]pyrimidin-5-yl)- benzylamino)-N-(3,4- difluorobenzyl)-5- (trifluoromethyl)nicotinamide::US10030016, Example 331

SMILES Cn1cc(-c2ccc(CNc3ncc(cc3C(=O)NCc3ccc(F)c(F)c3)C(F)(F)F)cc2)c2c(N)cccc12

InChI Key InChIKey=ZXQMSUBIMXXJDZ-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 282451   

Target3-phosphoinositide-dependent protein kinase 1 [51-359](Human)
Sunesis Pharmaceuticals

US Patent
LigandPNGBDBM282451(2-(4-(4-amino-7-methyl-7H- pyrrolo[2,3-d]pyrimidin...)
Affinity DataIC50: 100nMAssay Description:PDK1 (amino acids 51-359) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) were expressed as N-terminally tagged GST fusi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2018
Entry Details
US Patent