BDBM282697 (R)-3-((3-Amino-4-(difluoromethyl)-2,2-difluoro-1,1- dioxido-2,3-dihydrobenzo[b]thiophen-5-yl)oxy)-5- fluorobenzonitrile::US9884843, Compound 41

SMILES N[C@@H]1c2c(ccc(Oc3cc(F)cc(c3)C#N)c2C(F)F)S(=O)(=O)C1(F)F

InChI Key InChIKey=IJAODYCPXPVVKD-UHFFFAOYSA-N

Data  1 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 282697   

TargetVascular endothelial growth factor A(Human)
Peloton Therapeutics

US Patent
LigandPNGBDBM282697(US9884843, Compound 41 | (R)-3-((3-Amino-4-(difluo...)
Affinity DataIC50: 69nMpH: 7.5Assay Description:The total assay volume was about 100 μL in the following configuration: 2-μL compound in DMSO, 88 μL buffer with protein and probe and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2019
Entry Details
US Patent

TargetVascular endothelial growth factor A(Human)
Peloton Therapeutics

US Patent
LigandPNGBDBM282697(US9884843, Compound 41 | (R)-3-((3-Amino-4-(difluo...)
Affinity DataEC50:  680nMAssay Description:About 7500 of 786-O cells in 180 μL of growth medium were seeded into each well of a 96 well plate with white clear bottom on the first day (07-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2019
Entry Details
US Patent