BDBM283628 N-((6-amino-2,4-dimethylpyridin-3-yl)methyl)- 2-((3-chloroquinolin-6- yl)(hydroxy)methyl)isonicotinamide::US10023557, Example 275::US10308637, Example 275

SMILES Cc1cc(N)nc(C)c1CNC(=O)c1ccnc(c1)C(O)c1ccc2ncc(Cl)cc2c1

InChI Key InChIKey=FZBWFJGOXURHDV-UHFFFAOYSA-N

Data  2 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 283628   

TargetPlasma kallikrein(Human)
Lifesci Pharmaceuticals

US Patent
LigandPNGBDBM283628(US10023557, Example 275 | N-((6-amino-2,4-dimethyl...)
Affinity DataIC50: 100nMpH: 7.5Assay Description:A 10 mM solution of the test compound was made in DMSO. This solution was serially diluted 1:5 in DMSO to yield 2000, 400, 80, 16, 3.2, 0.64, 0.128, ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2019
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Lifesci Pharmaceuticals

US Patent
LigandPNGBDBM283628(US10023557, Example 275 | N-((6-amino-2,4-dimethyl...)
Affinity DataIC50: 100nMAssay Description:A 10 mM solution of the test compound was made in DMSO. This solution was serially diluted 1:5 in DMSO to yield 2000, 400, 80, 16, 3.2, 0.64, 0.128, ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/15/2020
Entry Details
US Patent

TargetPlasma kallikrein(Human)
Lifesci Pharmaceuticals

US Patent
LigandPNGBDBM283628(US10023557, Example 275 | N-((6-amino-2,4-dimethyl...)
Affinity DataEC50:  550nMAssay Description:The test compounds at various concentrations, also prepared by serial dilutions as described above, are added to the test wells. The volume of test c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2019
Entry Details
US Patent