BDBM283635 N-((3-chloro-4-fluoro-1H-indol-5-yl)methyl)-2- ((3-ethylquinolin-6-yl)methyl)isonicotinamide::US10023557, Example 282::US10308637, Example 282

SMILES CCc1cnc2ccc(Cc3cc(ccn3)C(=O)NCc3ccc4[nH]cc(Cl)c4c3F)cc2c1

InChI Key InChIKey=PETIZYZCCWGRAH-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 283635   

TargetPlasma kallikrein(Human)
Lifesci Pharmaceuticals

US Patent
LigandPNGBDBM283635(US10023557, Example 282 | N-((3-chloro-4-fluoro-1H...)
Affinity DataIC50: 100nMpH: 7.5Assay Description:A 10 mM solution of the test compound was made in DMSO. This solution was serially diluted 1:5 in DMSO to yield 2000, 400, 80, 16, 3.2, 0.64, 0.128, ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2019
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Lifesci Pharmaceuticals

US Patent
LigandPNGBDBM283635(US10023557, Example 282 | N-((3-chloro-4-fluoro-1H...)
Affinity DataIC50: 100nMAssay Description:A 10 mM solution of the test compound was made in DMSO. This solution was serially diluted 1:5 in DMSO to yield 2000, 400, 80, 16, 3.2, 0.64, 0.128, ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/15/2020
Entry Details
US Patent