BDBM283978 6-(1-methyl-1H- pyrazol-4-yl)-4-(6-(4- (2-(pyridin-2- yl)acetyl)piperazin-1- yl)pyridin-3- yl)pyrazolo[1,5- a]pyridine-3- carbonitrile::US10023570, Example 5::US10174027, Example 5

SMILES Cn1cc(cn1)-c1cc(-c2ccc(nc2)N2CCN(CC2)C(=O)Cc2ccccn2)c2c(cnn2c1)C#N

InChI Key InChIKey=MIXWDAIHJYHCSP-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 283978   

LigandPNGBDBM283978(US10023570, Example 5 | 6-(1-methyl-1H- pyrazol-4-...)
Affinity DataIC50: 4.60nMpH: 7.4Assay Description:Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF KinEASE -TK a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/10/2019
Entry Details
Go to US Patent

LigandPNGBDBM283978(US10023570, Example 5 | 6-(1-methyl-1H- pyrazol-4-...)
Affinity DataIC50: 32nMpH: 7.4Assay Description:Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF KinEASE -TK a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/10/2019
Entry Details
Go to US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Array Biopharma

US Patent
LigandPNGBDBM283978(US10023570, Example 5 | 6-(1-methyl-1H- pyrazol-4-...)
Affinity DataIC50: 4.60nMAssay Description:Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF KinEASE-TK as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
Go to US Patent

LigandPNGBDBM283978(US10023570, Example 5 | 6-(1-methyl-1H- pyrazol-4-...)
Affinity DataIC50: 32nMAssay Description:Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF KinEASE-TK as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
Go to US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Array Biopharma

US Patent
LigandPNGBDBM283978(US10023570, Example 5 | 6-(1-methyl-1H- pyrazol-4-...)
Affinity DataIC50: 4.60nMAssay Description:Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF KinEASE -TK a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
Go to US Patent

LigandPNGBDBM283978(US10023570, Example 5 | 6-(1-methyl-1H- pyrazol-4-...)
Affinity DataIC50: 32nMAssay Description:Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF KinEASE -TK a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
Go to US Patent