BDBM283987 (R)-6-(1-methyl-1H- pyrazol-4-yl)-4-(6-(4- (2- phenylpropanoyl)piperazin- 1-yl)pyridin-3- yl)pyrazolo[1,5- a]pyridine-3- carbonitrile::US10023570, Example 14::US10174027, Example 14

SMILES C[C@@H](C(=O)N1CCN(CC1)c1ccc(cn1)-c1cc(cn2ncc(C#N)c12)-c1cnn(C)c1)c1ccccc1

InChI Key InChIKey=ZZIDHRWMVCQFJW-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 283987   

LigandPNGBDBM283987(US10023570, Example 14 | (R)-6-(1-methyl-1H- pyraz...)
Affinity DataIC50: 4.40nMpH: 7.4Assay Description:Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF KinEASE -TK a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/10/2019
Entry Details
Go to US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Array Biopharma

US Patent
LigandPNGBDBM283987(US10023570, Example 14 | (R)-6-(1-methyl-1H- pyraz...)
Affinity DataIC50: 4.40nMAssay Description:Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF KinEASE-TK as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
Go to US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Array Biopharma

US Patent
LigandPNGBDBM283987(US10023570, Example 14 | (R)-6-(1-methyl-1H- pyraz...)
Affinity DataIC50: 4.40nMAssay Description:Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF KinEASE -TK a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
Go to US Patent