BDBM284348 6-(1-methyl-1H-pyrazol- 4-yl)-4-(6-(4-(2- morpholinobenzoyl)pipera zin-1-yl)pyridin-3- yl)pyrazolo[1,5- a]pyridine-3-carbonitrile bis(2,2,2-trifluoroacetate)::US10023570, Example 358::US10174027, Example 358

SMILES Cn1cc(cn1)-c1cc(-c2ccc(nc2)N2CCN(CC2)C(=O)c2ccccc2N2CCOCC2)c2c(cnn2c1)C#N

InChI Key InChIKey=JPKXGDUFCJRFFT-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 284348   

LigandPNGBDBM284348(US10023570, Example 358 | 6-(1-methyl-1H-pyrazol- ...)
Affinity DataIC50: 5.10nMpH: 7.4Assay Description:Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF KinEASE -TK a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/10/2019
Entry Details
Go to US Patent

LigandPNGBDBM284348(US10023570, Example 358 | 6-(1-methyl-1H-pyrazol- ...)
Affinity DataIC50: 57nMpH: 7.4Assay Description:Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF KinEASE -TK a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/10/2019
Entry Details
Go to US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Array Biopharma

US Patent
LigandPNGBDBM284348(US10023570, Example 358 | 6-(1-methyl-1H-pyrazol- ...)
Affinity DataIC50: 5.10nMAssay Description:Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF KinEASE-TK as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
Go to US Patent

LigandPNGBDBM284348(US10023570, Example 358 | 6-(1-methyl-1H-pyrazol- ...)
Affinity DataIC50: 57nMAssay Description:Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF KinEASE-TK as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
Go to US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Array Biopharma

US Patent
LigandPNGBDBM284348(US10023570, Example 358 | 6-(1-methyl-1H-pyrazol- ...)
Affinity DataIC50: 5.10nMAssay Description:Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF KinEASE -TK a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
Go to US Patent

LigandPNGBDBM284348(US10023570, Example 358 | 6-(1-methyl-1H-pyrazol- ...)
Affinity DataIC50: 57nMAssay Description:Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF KinEASE -TK a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
Go to US Patent