BDBM284379 4-(6-(4-(3- ethylpyrrolidine-1- carbonyl)piperazin-1- yl)pyridin-3-yl)-6-(1- methyl-1H-pyrazol-4- yl)pyrazolo[1,5-a]pyridine- 3-carbonitrile::US10023570, Example 389::US10174027, Example 389

SMILES CCC1CCN(C1)C(=O)N1CCN(CC1)c1ccc(cn1)-c1cc(cn2ncc(C#N)c12)-c1cnn(C)c1

InChI Key InChIKey=YSLNRBYOPKMOGQ-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 284379   

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Array Biopharma

US Patent
LigandPNGBDBM284379(US10023570, Example 389 | 4-(6-(4-(3- ethylpyrroli...)
Affinity DataIC50: 5.40nMAssay Description:Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF KinEASE -TK a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
US Patent

LigandPNGBDBM284379(US10023570, Example 389 | 4-(6-(4-(3- ethylpyrroli...)
Affinity DataIC50: 5.40nMpH: 7.4Assay Description:Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF KinEASE -TK a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/10/2019
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Array Biopharma

US Patent
LigandPNGBDBM284379(US10023570, Example 389 | 4-(6-(4-(3- ethylpyrroli...)
Affinity DataIC50: 5.40nMAssay Description:Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF KinEASE-TK as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
US Patent

LigandPNGBDBM284379(US10023570, Example 389 | 4-(6-(4-(3- ethylpyrroli...)
Affinity DataIC50: 29.6nMAssay Description:Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF KinEASE -TK a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
US Patent

LigandPNGBDBM284379(US10023570, Example 389 | 4-(6-(4-(3- ethylpyrroli...)
Affinity DataIC50: 29.6nMpH: 7.4Assay Description:Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF KinEASE -TK a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/10/2019
Entry Details
US Patent

LigandPNGBDBM284379(US10023570, Example 389 | 4-(6-(4-(3- ethylpyrroli...)
Affinity DataIC50: 29.6nMAssay Description:Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF KinEASE-TK as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
US Patent